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Study · Animal study (in vivo) · mouse · 2008

6 results

Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient mice.

Kawashima S, Sakihara S, Kageyama K, Nigawara T, Suda T

Peptides26 Sept 2008Cited by 15 (Europe PMC)

PMID18930089 (opens in a new tab)DOI10.1016/j.peptides.2008.09.010 (opens in a new tab)PepBankPUB-18930089
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice, intracerebroventricular NDP-MSH suppressed food intake.

    In plain wordsIn mice, NDP-MSH given into the brain reduced food intake.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseFood intake in wild-type mice
    Study

    mousen: not reported in source

    Wild-type mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Intracerebroventricular administration of NDP-MSH, a synthetic alpha-MSH analogue, suppressed food intake in wild-type (WT) mice.
    1 context sentence
    Summary · context
    In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type mice, pretreatment with the CRF receptor antagonist astressin abolished the food intake suppression by NDP-MSH.

    In plain wordsIn mice, blocking CRF receptors with astressin removed the food-reducing effect of NDP-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeFood intake with CRF receptor antagonist astressin
    Study

    mousen: not reported in source

    Wild-type mice with astressin pretreatment
    Comparator
    NDP-MSH without astressin
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    This effect was abolished by pretreatment with a non-selective CRF receptor antagonist, astressin, suggesting that the effect of alpha-MSH-induced anorexia was mediated by a CRF receptor.
    2 context sentences
    Summary · context
    Intracerebroventricular administration of NDP-MSH, a synthetic alpha-MSH analogue, suppressed food intake in wild-type (WT) mice.
    Summary · context
    In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In CRF-deficient mice, NDP-MSH did not affect food intake at the early phase (0-4h).

    In plain wordsIn mice lacking CRF, NDP-MSH did not change food intake in the first hours.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeFood intake at early phase (0-4h) in CRF-deficient mice
    Study

    mousen: not reported in source

    CRF-deficient (CRFKO) mice
    Comparator
    Wild-type mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In CRFKO mice, administration with NDP-MSH did not affect food intake at an early phase (0-4h).
    1 context sentence
    Summary · context
    In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, hypothalamic CRF mRNA levels were significantly increased in NDP-MSH-treated animals.

    In plain wordsIn mice, NDP-MSH raised the level of CRF messenger RNA in the brain region that controls appetite.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseHypothalamic CRF mRNA
    Study

    mousen: not reported in source

    Mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    In addition, CRF mRNA levels in the hypothalamus were significantly increased in NDP-MSH-treated mice.
    1 context sentence
    Summary · context
    In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In CRF-deficient mice, NDP-MSH suppressed food intake at the late phase (4-12h), similar to wild-type mice.

    In plain wordsIn mice lacking CRF, NDP-MSH still reduced food intake later in the day, as it did in normal mice.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseFood intake at late phase (4-12h) in CRF-deficient mice
    Study

    mousen: not reported in source

    CRF-deficient (CRFKO) mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    On the other hand, NDP-MSH administered to CRFKO mice led to suppressed food intake at the late phase (4-12h), similar to the effect in WT mice.
    1 context sentence
    Summary · context
    In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type, CRF-deficient and corticosterone-replaced CRF-deficient mice, NDP-MSH similarly reduced food intake during the late phase.

    In plain wordsIn mice, NDP-MSH reduced later food intake in normal mice, mice lacking CRF, and mice lacking CRF with added corticosterone.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseLate-phase food intake in CRFKO mice with corticosterone replacement
    Study

    mousen: not reported in source

    Wild-type, CRFKO and CRFKO mice with corticosterone replacement
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (mouse).

    Source sentences

    Summary
    Further, NDP-MSH similarly reduced food intake during the late phase in all types of mice, including WT, CRFKO, and CRFKO with corticosterone replacement.
    1 context sentence
    Summary · context
    In the present study, we examined whether CRF and its receptors are involved in the anorexic effect of alpha-MSH, using CRF-deficient (CRFKO) mice and a CRF receptor antagonist.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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