Weak functional coupling of the melanocortin-1 receptor expressed in human adipocytes.

Hoch M, Hirzel E, Lindinger P, Eberle AN, Linscheid P, Martin I, Peters T, Peterli R

Journal of receptor and signal transduction research1 Jan 2008Cited by 12 (Europe PMC)

PMID18946769DOI10.1080/10799890802442622PepBankPUB-18946769

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In human adipose tissue explants, NDP-MSH did not affect lipolysis.
In plain wordsIn human fat tissue samples, NDP-MSH did not change fat breakdown.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeLipolysis in adipose tissue explants
Study
humann: not reported in source
Human adipose tissue explants
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
However, it did not affect lipolysis in these cells or in adipose tissue explants
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676903
02LabIn vitro (cells)Mechanism
In human MSC-derived adipocytes, NDP-MSH induced a weak cAMP signal.
In plain wordsIn human fat cells grown in the lab, NDP-MSH produced only a weak cell signal.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreasecAMP signal in MSC-derived adipocytes
Study
humann: not reported in source
Human MSC-derived adipocytes
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
This agonist induced a weak cAMP signal in MSC-derived adipocytes.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676901
03LabIn vitro (cells)Mechanism
In human MSC-derived adipocytes, NDP-MSH did not affect lipolysis.
In plain wordsIn human fat cells grown in the lab, NDP-MSH did not change fat breakdown.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeLipolysis in MSC-derived adipocytes
Study
humann: not reported in source
Human MSC-derived adipocytes
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
However, it did not affect lipolysis in these cells or in adipose tissue explants
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676902
04LabIn vitro (cells)Mechanism
In human adipocytes and adipose tissue explants, NDP-MSH did not modulate cytokine release upon LPS stimulation.
In plain wordsIn human fat cells and tissue in the lab, NDP-MSH did not change release of inflammation signals after a bacterial trigger.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeCytokine release after LPS stimulation
Study
humann: not reported in source
Human MSC-derived adipocytes
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
nor did it modulate cytokine release and mRNA expression of IL-6, IL-8, and TNF-alpha upon LPS stimulation
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676904
05LabIn vitro (cells)Mechanism
In human adipocytes and adipose tissue explants, NDP-MSH did not modulate mRNA expression of IL-6, IL-8 and TNF-alpha upon LPS stimulation.
In plain wordsIn human fat cells and tissue in the lab, NDP-MSH did not change gene activity of inflammation signals after a bacterial trigger.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeIL-6, IL-8 and TNF-alpha mRNA expression after LPS stimulation
Study
humann: not reported in source
Human MSC-derived adipocytes
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
nor did it modulate cytokine release and mRNA expression of IL-6, IL-8, and TNF-alpha upon LPS stimulation
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676905
06LabIn vitro (cells)Mechanism
In undifferentiated human MSCs, NDP-MSH did not alter the metabolic rate.
In plain wordsIn human stem cells grown in the lab, NDP-MSH did not change the cell metabolic rate.
Peptide
Melanotan I (afamelanotide)
Outcome
No significant changeMetabolic rate of undifferentiated MSCs
Study
humann: not reported in source
Human undifferentiated MSCs
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
In undifferentiated MSCs, NDP-MSH did not alter the metabolic rate
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676906
07LabIn vitro (cells)Mechanism
In undifferentiated human MSCs, NDP-MSH had a significant antiproliferative effect.
In plain wordsIn human stem cells grown in the lab, NDP-MSH slowed cell growth.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseProliferation of undifferentiated MSCs
Study
humann: not reported in source
Human undifferentiated MSCs
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
In undifferentiated MSCs, NDP-MSH did not alter the metabolic rate, but it showed a significant antiproliferative effect.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular output signals (cAMP, lipolysis, secretion of IL-6, IL-10, and TNF-alpha), as well as effects on the metabolic rate and proliferation of human MSCs were analyzed by standard assays, exposing undifferentiated and differentiated MSCs and, in part, human adipose tissue explants to the pot…
Report a problemFND-1894676907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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