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Study · Animal study (in vivo) · rat · 2008

4 results

Treatment with alpha-melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts.

Colombo G, Sordi A, Lonati C, Carlin A, Turcatti F, Leonardi P, Gatti S, Catania A

Brain, behavior, and immunity4 Jan 2008Cited by 10 (Europe PMC)

PMID18178058 (opens in a new tab)DOI10.1016/j.bbi.2007.11.009 (opens in a new tab)PepBankPUB-18178058
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with heart allografts, NDP-alpha-MSH partly reversed the inhibition of calcium regulatory protein transcription compared with saline treatment.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH partly restored gene activity of calcium-handling proteins compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCalcium regulatory protein transcription in heart allografts
    Study

    ratn: not reported in source

    Heterotopic heart transplantation, Brown Norway donor hearts into Lewis rats
    Comparator
    Allografts from saline-treated rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 microg every 12h · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    NDP-alpha-MSH administration partly reversed inhibition of protein transcription
    2 context sentences
    Summary · context
    (3) allografts from rats treated with the synthetic alpha-MSH analog Nle4-DPhe7-alpha-MSH (NDP-alpha-MSH) (100 microg i.p. every 12h)
    Summary · context
    Hearts from Brown Norway rats were transplanted heterotopically into MHC incompatible Lewis rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with heart allografts, NDP-alpha-MSH almost completely prevented the loss of calcium regulatory proteins compared with saline treatment.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH almost fully prevented loss of calcium-handling proteins compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseCalcium regulatory protein level in heart allografts
    Study

    ratn: not reported in source

    Heterotopic heart transplantation, Brown Norway donor hearts into Lewis rats
    Comparator
    Allografts from saline-treated rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 microg every 12h · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    almost completely prevented protein loss.
    2 context sentences
    Summary · context
    (3) allografts from rats treated with the synthetic alpha-MSH analog Nle4-DPhe7-alpha-MSH (NDP-alpha-MSH) (100 microg i.p. every 12h)
    Summary · context
    Hearts from Brown Norway rats were transplanted heterotopically into MHC incompatible Lewis rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with heart allografts, NDP-alpha-MSH treatment significantly preserved Epac1 protein, which transplantation injury had markedly reduced.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH kept Epac1 protein from falling after transplant, compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseEpac1 protein in heart allografts
    Study

    ratn: not reported in source

    Heterotopic heart transplantation, Brown Norway donor hearts into Lewis rats
    Comparator
    Allografts from saline-treated rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 microg every 12h · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    NDP-alpha-MSH treatment significantly preserved both Epac1 protein and mRNA in the allografts.
    3 context sentences
    Summary · context
    Transplantation injury markedly reduced Epac1.
    Summary · context
    (3) allografts from rats treated with the synthetic alpha-MSH analog Nle4-DPhe7-alpha-MSH (NDP-alpha-MSH) (100 microg i.p. every 12h)
    Summary · context
    Hearts from Brown Norway rats were transplanted heterotopically into MHC incompatible Lewis rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with heart allografts, NDP-alpha-MSH treatment significantly preserved Epac1 mRNA, which transplantation injury had markedly reduced.

    In plain wordsIn rats with transplanted hearts, NDP-alpha-MSH kept Epac1 gene activity from falling after transplant, compared with saline.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseEpac1 mRNA in heart allografts
    Study

    ratn: not reported in source

    Heterotopic heart transplantation, Brown Norway donor hearts into Lewis rats
    Comparator
    Allografts from saline-treated rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 microg every 12h · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    NDP-alpha-MSH treatment significantly preserved both Epac1 protein and mRNA in the allografts.
    3 context sentences
    Summary · context
    Transplantation injury markedly reduced Epac1.
    Summary · context
    (3) allografts from rats treated with the synthetic alpha-MSH analog Nle4-DPhe7-alpha-MSH (NDP-alpha-MSH) (100 microg i.p. every 12h)
    Summary · context
    Hearts from Brown Norway rats were transplanted heterotopically into MHC incompatible Lewis rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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