Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism.

Ottani A, Giuliani D, Galantucci M, Spaccapelo L, Novellino E, Grieco P, Jochem J, Guarini S

European journal of pharmacology10 Apr 2010Cited by 36 (Europe PMC)

PMID20385118DOI10.1016/j.ejphar.2010.03.052PepBankPUB-20385118

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with prolonged myocardial ischemia/reperfusion, intravenous NDP-alpha-MSH reduced TNF-alpha levels in the left ventricle versus saline.
In plain wordsIn rats with a heart attack model, NDP-alpha-MSH lowered TNF-alpha in the heart more than saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseLeft ventricle TNF-alpha levels
Study
ratn: not reported in source
Rat model of 30-min left anterior descending coronary artery occlusion with 2-h reperfusion
Comparator
Saline
Outcome group
Inflammation markers · Cardiovascular
Studied dose
Dose not stated · intravenous · during coronary artery occlusionAs given in this study (rat).
Source sentences
Summary
Intravenous treatment, during coronary artery occlusion, with the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) produced a reduction in TNF-alpha levels and in the activity of JNK and caspase-3, associated with marked activation of the pro-survival kinase…
1 context sentence(design, population, supporting numbers)
Summary · context
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min.
Report a problemFND-2038511801
02AnimalAnimal study (in vivo)Mechanism
In rats with prolonged myocardial ischemia/reperfusion, NDP-alpha-MSH reduced JNK activity in the left ventricle versus saline.
In plain wordsIn rats with a heart attack model, NDP-alpha-MSH lowered JNK activity in the heart compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseLeft ventricle JNK activity
Study
ratn: not reported in source
Rat model of 30-min left anterior descending coronary artery occlusion with 2-h reperfusion
Comparator
Saline
Outcome group
Inflammation markers · Cardiovascular
Studied dose
Dose not stated · intravenous · during coronary artery occlusionAs given in this study (rat).
Source sentences
Summary
Intravenous treatment, during coronary artery occlusion, with the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) produced a reduction in TNF-alpha levels and in the activity of JNK and caspase-3, associated with marked activation of the pro-survival kinase…
1 context sentence(design, population, supporting numbers)
Summary · context
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min.
Report a problemFND-2038511802
03AnimalAnimal study (in vivo)Mechanism
In rats with prolonged myocardial ischemia/reperfusion, NDP-alpha-MSH reduced caspase-3 activity in the left ventricle versus saline.
In plain wordsIn rats with a heart attack model, NDP-alpha-MSH lowered caspase-3 activity, a cell-death marker, in the heart compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseLeft ventricle caspase-3 activity
Study
ratn: not reported in source
Rat model of 30-min left anterior descending coronary artery occlusion with 2-h reperfusion
Comparator
Saline
Outcome group
Myocardial injury · Cardiovascular
Studied dose
Dose not stated · intravenous · during coronary artery occlusionAs given in this study (rat).
Source sentences
Summary
Intravenous treatment, during coronary artery occlusion, with the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) produced a reduction in TNF-alpha levels and in the activity of JNK and caspase-3, associated with marked activation of the pro-survival kinase…
1 context sentence(design, population, supporting numbers)
Summary · context
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min.
Report a problemFND-2038511803
04AnimalAnimal study (in vivo)Mechanism
In rats with prolonged myocardial ischemia/reperfusion, NDP-alpha-MSH was associated with marked activation of the pro-survival kinases ERK 1/2 in the left ventricle versus saline.
In plain wordsIn rats with a heart attack model, NDP-alpha-MSH raised activation of the survival kinases ERK 1/2 in the heart compared with saline.
Peptide
Melanotan I (afamelanotide)
Outcome
IncreaseLeft ventricle ERK 1/2 activation
Study
ratn: not reported in source
Rat model of 30-min left anterior descending coronary artery occlusion with 2-h reperfusion
Comparator
Saline
Outcome group
Myocardial injury · Cardiovascular
Studied dose
Dose not stated · intravenous · during coronary artery occlusionAs given in this study (rat).
Source sentences
Summary
Intravenous treatment, during coronary artery occlusion, with the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) produced a reduction in TNF-alpha levels and in the activity of JNK and caspase-3, associated with marked activation of the pro-survival kinase…
1 context sentence(design, population, supporting numbers)
Summary · context
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min.
Report a problemFND-2038511804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with prolonged myocardial ischemia/reperfusion, NDP-alpha-MSH attenuated infarct size versus saline.
In plain wordsIn rats with a heart attack model, NDP-alpha-MSH made the damaged heart area smaller than saline.
Peptide
Melanotan I (afamelanotide)
Outcome
DecreaseInfarct size
Study
ratn: not reported in source
Rat model of 30-min left anterior descending coronary artery occlusion with 2-h reperfusion
Comparator
Saline
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
Dose not stated · intravenous · during coronary artery occlusionAs given in this study (rat).
Source sentences
Summary
Intravenous treatment, during coronary artery occlusion, with the melanocortin analog [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone (NDP-alpha-MSH) produced a reduction in TNF-alpha levels and in the activity of JNK and caspase-3, associated with marked activation of the pro-survival kinase…
1 context sentence(design, population, supporting numbers)
Summary · context
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min.
Report a problemFND-2038511805
06AnimalAnimal study (in vivo)Mechanism
In rats with prolonged myocardial ischemia/reperfusion, bilateral cervical vagotomy blunted the protective effects of NDP-alpha-MSH.
In plain wordsIn rats with a heart attack model, cutting the vagus nerve weakened the protective effects of NDP-alpha-MSH.
Peptide
Melanotan I (afamelanotide)
Outcome
Not applicableProtective effects of NDP-alpha-MSH after bilateral cervical vagotomy
Study
ratn: not reported in source
Rat model of 30-min left anterior descending coronary artery occlusion with 2-h reperfusion
Outcome group
Myocardial injury · Cardiovascular
Studied dose
Dose not stated · intravenous · during coronary artery occlusionAs given in this study (rat).
Source sentences
Summary
Bilateral cervical vagotomy blunted the protective effects of NDP-alpha-MSH.
1 context sentence(design, population, supporting numbers)
Summary · context
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30 min.
Report a problemFND-2038511806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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