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Study · Animal study (in vivo) · 2013

13 results

NDP-MSH inhibits neutrophil migration through nicotinic and adrenergic receptors in experimental peritonitis.

Figueiredo J, Ferreira AE, Silva RL, Ulloa L, Grieco P, Cunha TM, Ferreira SH, Cunha Fde Q, Kanashiro A

Naunyn-Schmiedeberg's archives of pharmacology22 Jan 2013Cited by 10 (Europe PMC)

PMID23338711 (opens in a new tab)DOI10.1007/s00210-013-0834-7 (opens in a new tab)PepBankPUB-23338711
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, subcutaneous pretreatment with NDP-MSH decreased neutrophil trafficking into the peritoneal cavity in a dose-dependent manner.

    In plain wordsIn an animal model of peritonitis, NDP-MSH given before the trigger reduced neutrophil movement into the abdomen, more so at higher doses.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNeutrophil migration into the peritoneal cavity
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    Herein, subcutaneous pretreatment with NDP-MSH decreased neutrophil trafficking in the peritoneal cavity in a dose-dependent manner.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH inhibited vascular leakage.

    In plain wordsIn an animal model of peritonitis, NDP-MSH reduced leakage from blood vessels.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseVascular leakage
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH inhibited leukocyte rolling.

    In plain wordsIn an animal model of peritonitis, NDP-MSH reduced white blood cell rolling along vessel walls.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseLeukocyte rolling
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH inhibited leukocyte adhesion.

    In plain wordsIn an animal model of peritonitis, NDP-MSH reduced white blood cell sticking to vessel walls.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseLeukocyte adhesion
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH reduced peritoneal macrophage inflammatory protein 2 production.

    In plain wordsIn an animal model of peritonitis, NDP-MSH lowered the inflammatory signal macrophage inflammatory protein 2.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreasePeritoneal macrophage inflammatory protein 2
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH did not reduce TNF-alpha production.

    In plain wordsIn an animal model of peritonitis, NDP-MSH did not lower TNF-alpha.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changePeritoneal TNF-alpha production
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH did not reduce IL-1beta production.

    In plain wordsIn an animal model of peritonitis, NDP-MSH did not lower IL-1beta.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changePeritoneal IL-1beta production
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH did not change IL-10 production.

    In plain wordsIn an animal model of peritonitis, NDP-MSH did not change IL-10.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changePeritoneal IL-10 production
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, NDP-MSH did not reduce keratinocyte-derived chemokine production.

    In plain wordsIn an animal model of peritonitis, NDP-MSH did not lower keratinocyte-derived chemokine.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changePeritoneal keratinocyte-derived chemokine production
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    NDP-MSH inhibited vascular leakage, leukocyte rolling, and adhesion and reduced peritoneal macrophage inflammatory protein 2, but not TNF-alpha, IL-1beta, IL-10, and keratinocyte-derived chemokine production.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In carrageenin-induced peritonitis, pretreatment with the beta-adrenergic antagonist propranolol reverted the inhibition of neutrophil migration by NDP-MSH.

    In plain wordsIn an animal model of peritonitis, blocking beta-adrenergic receptors with propranolol removed the NDP-MSH effect on neutrophil movement.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableEffect of propranolol on NDP-MSH inhibition of neutrophil migration
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    In addition, the effect on neutrophil migration was reverted by the pretreatment with both propranolol (a nonselective beta-adrenergic antagonist) and mecamylamine (a nonselective nicotinic antagonist) but not by splenectomy surgery.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In carrageenin-induced peritonitis, pretreatment with the nicotinic antagonist mecamylamine reverted the inhibition of neutrophil migration by NDP-MSH.

    In plain wordsIn an animal model of peritonitis, blocking nicotinic receptors with mecamylamine removed the NDP-MSH effect on neutrophil movement.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableEffect of mecamylamine on NDP-MSH inhibition of neutrophil migration
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    In addition, the effect on neutrophil migration was reverted by the pretreatment with both propranolol (a nonselective beta-adrenergic antagonist) and mecamylamine (a nonselective nicotinic antagonist) but not by splenectomy surgery.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In carrageenin-induced peritonitis, splenectomy did not revert the inhibition of neutrophil migration by NDP-MSH.

    In plain wordsIn an animal model of peritonitis, removing the spleen did not remove the NDP-MSH effect on neutrophil movement.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeEffect of splenectomy on NDP-MSH inhibition of neutrophil migration
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study.

    Source sentences

    Summary
    In addition, the effect on neutrophil migration was reverted by the pretreatment with both propranolol (a nonselective beta-adrenergic antagonist) and mecamylamine (a nonselective nicotinic antagonist) but not by splenectomy surgery.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In carrageenin-induced peritonitis, intracerebroventricular NDP-MSH inhibited neutrophil migration, which indicates a role of the central nervous system.

    In plain wordsIn an animal model of peritonitis, NDP-MSH given into the brain reduced neutrophil movement, which points to a role of the nervous system.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseNeutrophil migration after intracerebroventricular NDP-MSH
    Study

    n: not reported in source

    Carrageenin-induced peritonitis model
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study.

    Source sentences

    Summary
    Moreover, NDP-MSH intracerebroventricular administration inhibited neutrophil migration, indicating participation of the central nervous system.
    1 context sentence
    Summary · context
    In the present study, we investigated the ability of [Nle4, D-Phe7]-melanocyte-stimulating hormone (NDP-MSH), a semisynthetic melanocortin compound, in the inhibition of neutrophil migration in carrageenin-induced peritonitis model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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