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Study · Animal study (in vivo) · rat · 1996

3 results

Structure-activity analysis for the effects of gamma-MSH/ACTH-like peptides on cerebral hemodynamics in rats.

Van Bergen P, Van Der Vaart JG, Kasbergen CM, Versteeg DH, De Wildt DJ

European journal of pharmacology1 Dec 1996Cited by 8 (Europe PMC)

PMID9016926 (opens in a new tab)DOI10.1016/s0014-2999(96)00806-0 (opens in a new tab)PepBankPUB-09016926
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In urethane-anesthetized rats, NDP-MSH did not induce a pressor effect.

    In plain wordsIn rats, NDP-MSH did not raise blood pressure.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changePressor response
    Study

    ratn: not reported in source

    urethane-anesthetized rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither the structurally related analog, [Nle4,D-Phe7]alpha-MSH (NDP-MSH), nor ACTH-(1-24) was able to induce a pressor effect or cerebral hemodynamic effects.
    1 context sentence
    Summary · context
    We now investigated whether these structural features are also important for the effects of these peptides on cerebral hemodynamics in urethane-anesthetized rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In urethane-anesthetized rats, NDP-MSH did not induce cerebral hemodynamic effects.

    In plain wordsIn rats, NDP-MSH did not change blood flow in the brain.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeCerebral hemodynamic effects
    Study

    ratn: not reported in source

    urethane-anesthetized rats
    Outcome group
    Cerebral blood flow · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither the structurally related analog, [Nle4,D-Phe7]alpha-MSH (NDP-MSH), nor ACTH-(1-24) was able to induce a pressor effect or cerebral hemodynamic effects.
    1 context sentence
    Summary · context
    We now investigated whether these structural features are also important for the effects of these peptides on cerebral hemodynamics in urethane-anesthetized rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In urethane-anesthetized rats, NDP-MSH had a depressor effect.

    In plain wordsIn rats, NDP-MSH lowered blood pressure.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseDepressor effect
    Study

    ratn: not reported in source

    urethane-anesthetized rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither the structurally related analog, [Nle4,D-Phe7]alpha-MSH (NDP-MSH), nor ACTH-(1-24) was able to induce a pressor effect or cerebral hemodynamic effects. In contrast, both compounds had a depressor effect.
    1 context sentence
    Summary · context
    We now investigated whether these structural features are also important for the effects of these peptides on cerebral hemodynamics in urethane-anesthetized rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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