AICAR (acadesine) studies: 330 papers with results
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- Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK.
Elksnis A · Clinical science (London, England : 1979) · 2021
In vitro (cells) · 1 result
- [Rosuvastatin protects acute myocardial infarction rats through autophagy regulation via AMPK signaling].
Song ZC · Zhonghua yi xue za zhi · 2018
In vitro (cells) · rat · 8 results
- Glycyrrhizin alleviates contrast-induced acute kidney injury via inhibiting HMGB1-mediated renal tubular epithelial cells ferroptosis.
Tian FY · Renal failure · 2025
In vitro (cells) · 1 result
- Role of Chitinase-3-like Protein 1 in Cardioprotection and Angiogenesis by Post-Infarction Exercise Training.
Li Z · Biomedicines · 2022
In vitro (cells) · 3 results
- Nicotinamide Mononucleotide (NMN) Improves the Senescence of Mouse Vascular Smooth Muscle Cells Induced by Ang II Through Activating p-AMPK/KLF4 Pathway.
Liang N · Pharmaceuticals (Basel, Switzerland) · 2025
In vitro (cells) · mouse · 9 results
- DNA aneuploidy-specific therapy for head and neck squamous cell carcinoma.
García Martínez J · Head & neck · 2015
In vitro (cells) · 4 results
- The effect of voluntary exercise on light cycle stress-induced metabolic resistance.
Moon HY · Physical activity and nutrition · 2023
In vitro (cells) · 1 result
- 5-aminoimidazole-4-carboxamide ribotide (AICAR) and its metabolites: metabolic and cytotoxic effects and accumulation during methotrexate treatment
Ha T · The Journal of nutritional biochemistry · 1994
In vitro (cells) · rabbit · 5 results
- GPR75 knockdown alleviates mitochondrial dysfunction in hippocampal neurons via AMPK pathway in diabetic mice.
Liu M · International immunopharmacology · 2025
In vitro (cells) · mouse · 3 results
- Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis.
Liu Z · Journal of innate immunity · 2025
In vitro (cells) · 2 results
- Adenylate kinase 4 (AK4) deficiency prevents vascular smooth muscle cell phenotypic switching by regulating mitochondrial dysfunction through AMPKα inactivation.
Zhang SM · Atherosclerosis · 2025
In vitro (cells) · 1 result
- Intermittent exercise alleviates MI-induced renal injury in mice via IGF-1.
Zhu W · Frontiers in physiology · 2025
In vitro (cells) · 1 result
- Mechanisms of aerobic exercise on doxorubicin-induced cardiomyocyte apoptosis: based on AMPK/PI3K/AKT signalling pathway.
Zhao Q · Life sciences · 2025
In vitro (cells) · 3 results
- [Regulatory Role of the AKT1/AMPK Pathway in Oxidative Stress of Lens Epithelial Cells in Cataract Patients].
Huang Y · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
In vitro (cells) · 7 results
- Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis.
Xu Y · Journal of cardiovascular translational research · 2026
In vitro (cells) · 2 results
- FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis.
Mao L · Biochemical and biophysical research communications · 2026
In vitro (cells) · 1 result
- AMP-activated protein kinase-Caspase 6 axis regulation alleviates the combined apoptotic damage caused by deoxynivalenol and fumonisin B1 in mammary glands.
Cao L · NPJ science of food · 2025
In vitro (cells) · bovine · 1 result
- Mechanisms of aerobic exercise on doxorubicin-induced cardiomyocyte apoptosis: based on AMPK/PI3K/AKT signalling pathway
Zhao Q · Life sciences · 2025
In vitro (cells) · 3 results
- Sophocarpine prevents LPS and IFN-γ-stimulated oxidative stress and neuroinflammation of BV-2 microglia by regulating the AMPK/NF-κB signaling pathway.
Guo S · Neurological research · 2026
In vitro (cells) · 2 results
- Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle.
Miyauchi Y · Calcified tissue international · 2025
In vitro (cells) · 3 results
- A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Liu Y · Nature chemical biology · 2021
Other design · 1 result
- Stevioside improves pancreatic beta-cell function during glucotoxicity via regulation of acetyl-CoA carboxylase.
Chen J · American journal of physiology. Endocrinology and metabolism · 2007
Other design · mouse (isolated islets) and species of ins-1e cells not reported · 1 result
- Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
Liu Z · European journal of pharmacology · 2024
Other design · mouse · 4 results
- Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway.
Zhao Q · Food & function · 2026
Other design · 2 results
- Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase.
Huimin C · Food research international (Ottawa, Ont.) · 2025
Measured the body's own AICAR (acadesine) · 5 results
- Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women.
Liong S · Journal of physiology and biochemistry · 2015
Not a test of AICAR (acadesine) alone · 12 results
- L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway.
Xia Z · Molecular biology reports · 2019
Not a test of AICAR (acadesine) alone · 10 results
- Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.
Ye JM · Diabetes · 2006
Not a test of AICAR (acadesine) alone · 9 results
- Ginsenoside Rb1 Ameliorates Autophagy of Hypoxia Cardiomyocytes from Neonatal Rats via AMP-Activated Protein Kinase Pathway.
Dai SN · Chinese journal of integrative medicine · 2019
Not a test of AICAR (acadesine) alone · 9 results
- Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.
Sun Y · Pharmacological research · 2014
Not a test of AICAR (acadesine) alone · 6 results
- A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.
Chen Q · Diabetologia · 2017
Not a test of AICAR (acadesine) alone · 5 results
- Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway.
Wu YL · Toxicology letters · 2016
Not a test of AICAR (acadesine) alone · 5 results
- Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner.
Misquitta NS · Human molecular genetics · 2023
Not a test of AICAR (acadesine) alone · 5 results
- PIK3CA mutation sensitizes breast cancer cells to synergistic therapy of PI3K inhibition and AMPK activation.
Liu S · Investigational new drugs · 2018
Not a test of AICAR (acadesine) alone · 5 results
- Aerobic Exercise Training Selectively Changes Oxysterol Levels and Metabolism Reducing Cholesterol Accumulation in the Aorta of Dyslipidemic Mice.
Ferreira GS · Frontiers in physiology · 2017
Not a test of AICAR (acadesine) alone · 5 results
- AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the functionality of intra-tumoral Tfh cells in the 4T1 mouse model.
Khamaru P · Cellular immunology · 2022
Not a test of AICAR (acadesine) alone · 5 results
- AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD.
Brandauer J · Frontiers in physiology · 2015
Not a test of AICAR (acadesine) alone · 4 results
- Combined effect of AMPK/PPAR agonists and exercise training in mdx mice functional performance.
Bueno Júnior CR · PloS one · 2012
Not a test of AICAR (acadesine) alone · 4 results
- Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).
Solskov L · Molecular and cellular biochemistry · 2012
Not a test of AICAR (acadesine) alone · 4 results
- Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells.
Vo HVT · Journal of enzyme inhibition and medicinal chemistry · 2026
Not a test of AICAR (acadesine) alone · 4 results
- FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice.
Liu TY · Diabetes · 2016
Not a test of AICAR (acadesine) alone · 3 results
- Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-β1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction.
Ma Y · International journal of molecular sciences · 2021
Not a test of AICAR (acadesine) alone · 3 results
- Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness.
Jin K · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
Not a test of AICAR (acadesine) alone · 3 results
- A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1.
Lv J · Acta cirurgica brasileira · 2018
Not a test of AICAR (acadesine) alone · 3 results
- Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Liu C · Cell biology international · 2017
Not a test of AICAR (acadesine) alone · 3 results
- Electroacupuncture alleviates traumatic brain injury by inhibiting autophagy via increasing IL-10 production and blocking the AMPK/mTOR signaling pathway in rats.
Wu T · Metabolic brain disease · 2023
Not a test of AICAR (acadesine) alone · 3 results
- Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.
Sakamoto K · The EMBO journal · 2005
Not a test of AICAR (acadesine) alone · 2 results
- Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.
Steinberg GR · The Journal of biological chemistry · 2010
Not a test of AICAR (acadesine) alone · 2 results
- Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling.
Paula FM · FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015
Not a test of AICAR (acadesine) alone · 2 results
- Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells.
Soo JS · Apoptosis : an international journal on programmed cell death · 2015
Not a test of AICAR (acadesine) alone · 2 results