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Study · Not a test of the peptide alone · 2023

5 results

Combinatorial treatment with exercise and AICAR potentiates the rescue of myotonic dystrophy type 1 mouse muscles in a sex-specific manner.

Misquitta NS, Ravel-Chapuis A, Jasmin BJ

Human molecular genetics1 Jan 2023Cited by 15 (Europe PMC)

PMID36048859 (opens in a new tab)DOI10.1093/hmg/ddac222 (opens in a new tab)PepBankPUB-36048859
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In DM1 mice, swimming exercise additively enhanced AICAR-associated reduction of nuclear toxic CUGexp RNA foci.

    In plain wordsIn mice with DM1, exercise plus AICAR reduced toxic RNA accumulation more than AICAR alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNuclear CUGexp RNA foci accumulation
    Study

    mousen: not reported in source

    male and female DM1 mice
    Comparator
    AICAR without swimming exercise
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Our data reveal that swimming exercise additively enhances the effect of AICAR in mitigating the nuclear accumulation of toxic CUGexp RNA foci.
    1 context sentence
    Summary · context
    Here, we employed a combinatorial approach with these AMPK activators and examined their joint impact on disease severity in male and female DM1 mice.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In DM1 mice, combined exercise and AICAR showed a trend toward enhanced reversal of MBNL1 sequestration.

    In plain wordsIn mice with DM1, exercise plus AICAR showed a trend toward greater reversal of MBNL1 trapping.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMBNL1 sequestration
    Study

    mousen: not reported in source

    male and female DM1 mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    In addition, our findings show a trend towards an enhanced reversal of MBNL1 sequestration and correction in pathogenic alternative splicing events.
    1 context sentence
    Summary · context
    Here, we employed a combinatorial approach with these AMPK activators and examined their joint impact on disease severity in male and female DM1 mice.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In DM1 mice, combined exercise and AICAR showed a trend toward enhanced correction of pathogenic alternative splicing.

    In plain wordsIn mice with DM1, exercise plus AICAR showed a trend toward greater correction of abnormal RNA splicing.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePathogenic alternative splicing
    Study

    mousen: not reported in source

    male and female DM1 mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    In addition, our findings show a trend towards an enhanced reversal of MBNL1 sequestration and correction in pathogenic alternative splicing events.
    1 context sentence
    Summary · context
    Here, we employed a combinatorial approach with these AMPK activators and examined their joint impact on disease severity in male and female DM1 mice.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In DM1 mice, combined exercise and AICAR promoted skeletal muscle fiber hypertrophy.

    In plain wordsIn mice with DM1, exercise plus AICAR promoted muscle fiber enlargement.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMuscle fiber hypertrophy
    Study

    mousen: not reported in source

    male and female DM1 mice
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Our results further demonstrate that the combinatorial impact of exercise and AICAR promotes muscle fiber hypertrophy in DM1 skeletal muscle.
    1 context sentence
    Summary · context
    Here, we employed a combinatorial approach with these AMPK activators and examined their joint impact on disease severity in male and female DM1 mice.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  5. 05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    Combined exercise and AICAR produced greater improvements in female than male DM1 mice.

    In plain wordsIn mice with DM1, females benefited more than males from exercise plus AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSex differences in combined treatment benefits
    Study

    mousen: not reported in source

    male and female DM1 mice
    Comparator
    male DM1 mice
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Importantly, these improvements occur in a sex-specific manner with greater benefits observed in female DM1 mice.
    1 context sentence
    Summary · context
    Here, we employed a combinatorial approach with these AMPK activators and examined their joint impact on disease severity in male and female DM1 mice.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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