FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice.

Liu TY, Xiong XQ, Ren XS, Zhao MX, Shi CX, Wang JJ, Zhou YB, Zhang F, Han Y, Gao XY, Chen Q, Li YH, Kang YM, Zhu GQ

Diabetes8 Aug 2016Cited by 115 (Europe PMC)

PMID27504012DOI10.2337/db16-0356PepBankPUB-27504012

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In energy-deprived FNDC5-deficient hepatocytes, AICAR restored attenuated autophagy.
In plain wordsIn cells from FNDC5-deficient mice, AICAR restored autophagy during energy deprivation.
Peptide
AICAR (acadesine)
Outcome
IncreaseAutophagy
Study
mousen: not reported in source
FNDC5-deficient hepatocytes under energy deprivation
Outcome group
Receptor activity and mechanism · Liver
Source sentences
Summary
Energy deprivation-induced autophagy, FAO, and AMPK activity were attenuated in FNDC5^-/- hepatocytes, which were restored by activating AMPK with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2750401201
02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In energy-deprived FNDC5-deficient hepatocytes, AICAR restored attenuated fatty acid oxidation.
In plain wordsIn cells from FNDC5-deficient mice, AICAR restored fatty acid oxidation during energy deprivation.
Peptide
AICAR (acadesine)
Outcome
IncreaseFatty acid oxidation
Study
mousen: not reported in source
FNDC5-deficient hepatocytes under energy deprivation
Outcome group
Lipids · Liver
Source sentences
Summary
Energy deprivation-induced autophagy, FAO, and AMPK activity were attenuated in FNDC5^-/- hepatocytes, which were restored by activating AMPK with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2750401202
03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In energy-deprived FNDC5-deficient hepatocytes, AICAR restored attenuated AMPK activity.
In plain wordsIn cells from FNDC5-deficient mice, AICAR restored AMPK activity during energy deprivation.
Peptide
AICAR (acadesine)
Outcome
IncreaseAMPK activity
Study
mousen: not reported in source
FNDC5-deficient hepatocytes under energy deprivation
Outcome group
Receptor activity and mechanism · Liver
Source sentences
Summary
Energy deprivation-induced autophagy, FAO, and AMPK activity were attenuated in FNDC5^-/- hepatocytes, which were restored by activating AMPK with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2750401203

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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