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Study · In vitro (cells) · 2026

2 results

Sophocarpine prevents LPS and IFN-γ-stimulated oxidative stress and neuroinflammation of BV-2 microglia by regulating the AMPK/NF-κB signaling pathway.

Guo S, Li T, Luan L, Deng J, Luo Y

Neurological research12 Aug 2025

PMID40795993 (opens in a new tab)DOI10.1080/01616412.2025.2545351 (opens in a new tab)PepBankPUB-40795993
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In stimulated BV-2 cells, AICAR intervention enhanced the antioxidant effects of sophocarpine.

    In plain wordsIn cells, AICAR enhanced sophocarpine's antioxidant effects compared with sophocarpine without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAntioxidant effects of sophocarpine
    Study

    n: not reported in source

    LPS- and IFN-γ-stimulated BV-2 microglia
    Comparator
    Sophocarpine without AICAR
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antioxidant and anti-inflammatory effects of ScP were found to be enhanced after AICAR intervention.
    1 context sentence
    Summary · context
    BV-2 cells were exposed to ScP, AMP-activated protein kinase (AMPK) agonist AICAR, and the AMPK inhibitor Compound C for 30 min before being treated with lipopolysaccharide (LPS) and IFN-γ for 24 h.
  2. 02LabIn vitro (cells)Mechanism

    In stimulated BV-2 cells, AICAR intervention enhanced the anti-inflammatory effects of sophocarpine.

    In plain wordsIn cells, AICAR enhanced sophocarpine's anti-inflammatory effects compared with sophocarpine without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAnti-inflammatory effects of sophocarpine
    Study

    n: not reported in source

    LPS- and IFN-γ-stimulated BV-2 microglia
    Comparator
    Sophocarpine without AICAR
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The antioxidant and anti-inflammatory effects of ScP were found to be enhanced after AICAR intervention.
    1 context sentence
    Summary · context
    BV-2 cells were exposed to ScP, AMP-activated protein kinase (AMPK) agonist AICAR, and the AMPK inhibitor Compound C for 30 min before being treated with lipopolysaccharide (LPS) and IFN-γ for 24 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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