In high-glucose-treated INS-1 cells, AICAR potentiated geniposide-induced HO-1 protein elevation.
In plain wordsIn cells, AICAR enhanced the rise in HO-1 protein with geniposide compared with geniposide alone.
- Peptide
- AICAR (acadesine)
- Outcome
- IncreaseHO-1 protein
- Study
ratn: not reported in source
INS-1 pancreatic beta cells- Comparator
- geniposide alone
- Outcome group
- Receptor activity and mechanism · Metabolic and weight
Source sentences
but AICAR, an AMPK activator, potentiated the role of geniposide on the protein levels of HO-1, Bcl-2, and Bax.
2 context sentences(design, population, supporting numbers)
Data suggested that geniposide obviously prevented the cell damage induced by high (25 mM) glucose in INS-1 cells, which increased the protein levels of cell apoptosis-associated enzymes, including heme oxygenase-1 (HO-1), and Bcl-2, but apparently attenuated the protein level of Bax, an apoptotic protein.
In the present study, we investigated the role of 5'-AMP-activated protein kinase (AMPK) in high glucose induced cell injury and explored the associated molecular mechanisms in rat INS-1 pancreatic β cells.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).