Skip to content

Study · In vitro (cells) · mouse · 2025

3 results

GPR75 knockdown alleviates mitochondrial dysfunction in hippocampal neurons via AMPK pathway in diabetic mice.

Liu M, Liu L, Liu W, Yu H, Yu S, Liu Z, Wang Y, Chen X, Miao Q, Yuan Y, Dai W, Hu J and 4 more

Show all authors

Zhang N, Sui J, Liu X, Zuo Z

International immunopharmacology2 Oct 2025Cited by 2 (Europe PMC)

PMID41043317 (opens in a new tab)DOI10.1016/j.intimp.2025.115638 (opens in a new tab)PepBankPUB-41043317
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In hippocampal neurons, AICAR mitigated GPR75-induced mitochondrial dysfunction.

    In plain wordsIn cells, AICAR reduced mitochondrial dysfunction induced by GPR75.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    mousen: not reported in source

    HT22 hippocampal neuronal cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the AMPK-activator AICAR mitigates GPR75-induced mitochondrial dysfunction, pyroptosis, and apoptosis.
    1 context sentence
    Summary · context
    In order to investigate the effect of GPR75 on DCD, we employed streptozotocin (STZ)-treated C57BL/6 J mice and high glucose (HG)-treated mouse hippocampal neuronal cells (HT22).
  2. 02LabIn vitro (cells)Mechanism

    In hippocampal neurons, AICAR mitigated GPR75-induced pyroptosis.

    In plain wordsIn cells, AICAR reduced pyroptosis induced by GPR75.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePyroptosis
    Study

    mousen: not reported in source

    HT22 hippocampal neuronal cells
    Outcome group
    Cell viability and death · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the AMPK-activator AICAR mitigates GPR75-induced mitochondrial dysfunction, pyroptosis, and apoptosis.
    1 context sentence
    Summary · context
    In order to investigate the effect of GPR75 on DCD, we employed streptozotocin (STZ)-treated C57BL/6 J mice and high glucose (HG)-treated mouse hippocampal neuronal cells (HT22).
  3. 03LabIn vitro (cells)Mechanism

    In hippocampal neurons, AICAR mitigated GPR75-induced apoptosis.

    In plain wordsIn cells, AICAR reduced apoptosis induced by GPR75.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseApoptosis
    Study

    mousen: not reported in source

    HT22 hippocampal neuronal cells
    Outcome group
    Cell viability and death · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the AMPK-activator AICAR mitigates GPR75-induced mitochondrial dysfunction, pyroptosis, and apoptosis.
    1 context sentence
    Summary · context
    In order to investigate the effect of GPR75 on DCD, we employed streptozotocin (STZ)-treated C57BL/6 J mice and high glucose (HG)-treated mouse hippocampal neuronal cells (HT22).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.