AMPK activator AICAR in combination with anti-mouse IL10 mAb restores the functionality of intra-tumoral Tfh cells in the 4T1 mouse model.

Khamaru P, Chakraborty S, Bhattacharyya A

Cellular immunology10 Nov 2022Cited by 6 (Europe PMC)

PMID36375313DOI10.1016/j.cellimm.2022.104639PepBankPUB-36375313

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In 4T1 tumor-bearing mice, AICAR plus anti-IL10 antibody increased intratumoral Tfh cell frequency.
In plain wordsIn mice with tumors, AICAR plus anti-IL10 antibody increased Tfh immune cells within tumors.
Peptide
AICAR (acadesine)
Outcome
IncreaseIntratumoral Tfh cell frequency
Study
mousen: not reported in source
4T1 breast carcinoma model
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
However, AICAR + anti-IL10 mAb increased the frequency of intratumoral Tfh cells, simultaneously downregulated Tfr cells; and improved humoral response by stimulating upregulation of memory B, GC B, and plasmablasts in tumor-draining, axillary, and mesenteric LNs of 4T1 mouse.
2 context sentences(design, population, supporting numbers)
Summary · context
4T1 cell-mediated TNBC breast cell carcinoma is a highly malignant mice tumor model which resembles an advanced stage of breast cancer in humans.
Summary · context
AMPK activator AICAR with or without anti-IL10 mAb was also used to ameliorate metabolic stress and exhaustion faced by immune cells.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3637531301
02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In 4T1 tumor-bearing mice, AICAR plus anti-IL10 antibody downregulated Tfr cells.
In plain wordsIn mice with tumors, AICAR plus anti-IL10 antibody reduced Tfr immune cells.
Peptide
AICAR (acadesine)
Outcome
DecreaseTfr cells
Study
mousen: not reported in source
4T1 breast carcinoma model
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
However, AICAR + anti-IL10 mAb increased the frequency of intratumoral Tfh cells, simultaneously downregulated Tfr cells; and improved humoral response by stimulating upregulation of memory B, GC B, and plasmablasts in tumor-draining, axillary, and mesenteric LNs of 4T1 mouse.
2 context sentences(design, population, supporting numbers)
Summary · context
4T1 cell-mediated TNBC breast cell carcinoma is a highly malignant mice tumor model which resembles an advanced stage of breast cancer in humans.
Summary · context
AMPK activator AICAR with or without anti-IL10 mAb was also used to ameliorate metabolic stress and exhaustion faced by immune cells.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3637531302
03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In 4T1 mice, AICAR plus anti-IL10 antibody increased memory B cells in tumor-draining, axillary, and mesenteric lymph nodes.
In plain wordsIn mice with tumors, AICAR plus anti-IL10 antibody increased memory B cells in the reported lymph nodes.
Peptide
AICAR (acadesine)
Outcome
IncreaseMemory B cells
Study
mousen: not reported in source
4T1 breast carcinoma model
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
However, AICAR + anti-IL10 mAb increased the frequency of intratumoral Tfh cells, simultaneously downregulated Tfr cells; and improved humoral response by stimulating upregulation of memory B, GC B, and plasmablasts in tumor-draining, axillary, and mesenteric LNs of 4T1 mouse.
2 context sentences(design, population, supporting numbers)
Summary · context
4T1 cell-mediated TNBC breast cell carcinoma is a highly malignant mice tumor model which resembles an advanced stage of breast cancer in humans.
Summary · context
AMPK activator AICAR with or without anti-IL10 mAb was also used to ameliorate metabolic stress and exhaustion faced by immune cells.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3637531303
04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In 4T1 mice, AICAR plus anti-IL10 antibody increased GC B cells in tumor-draining, axillary, and mesenteric lymph nodes.
In plain wordsIn mice with tumors, AICAR plus anti-IL10 antibody increased germinal center B cells in the reported lymph nodes.
Peptide
AICAR (acadesine)
Outcome
IncreaseGC B cells
Study
mousen: not reported in source
4T1 breast carcinoma model
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
However, AICAR + anti-IL10 mAb increased the frequency of intratumoral Tfh cells, simultaneously downregulated Tfr cells; and improved humoral response by stimulating upregulation of memory B, GC B, and plasmablasts in tumor-draining, axillary, and mesenteric LNs of 4T1 mouse.
2 context sentences(design, population, supporting numbers)
Summary · context
4T1 cell-mediated TNBC breast cell carcinoma is a highly malignant mice tumor model which resembles an advanced stage of breast cancer in humans.
Summary · context
AMPK activator AICAR with or without anti-IL10 mAb was also used to ameliorate metabolic stress and exhaustion faced by immune cells.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3637531304
05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In 4T1 mice, AICAR plus anti-IL10 antibody increased plasmablasts in tumor-draining, axillary, and mesenteric lymph nodes.
In plain wordsIn mice with tumors, AICAR plus anti-IL10 antibody increased plasmablasts in the reported lymph nodes.
Peptide
AICAR (acadesine)
Outcome
IncreasePlasmablasts
Study
mousen: not reported in source
4T1 breast carcinoma model
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
However, AICAR + anti-IL10 mAb increased the frequency of intratumoral Tfh cells, simultaneously downregulated Tfr cells; and improved humoral response by stimulating upregulation of memory B, GC B, and plasmablasts in tumor-draining, axillary, and mesenteric LNs of 4T1 mouse.
2 context sentences(design, population, supporting numbers)
Summary · context
4T1 cell-mediated TNBC breast cell carcinoma is a highly malignant mice tumor model which resembles an advanced stage of breast cancer in humans.
Summary · context
AMPK activator AICAR with or without anti-IL10 mAb was also used to ameliorate metabolic stress and exhaustion faced by immune cells.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3637531305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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