Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats.

Ye JM, Dzamko N, Hoy AJ, Iglesias MA, Kemp B, Kraegen E

Diabetes1 Oct 2006Cited by 52 (Europe PMC)

PMID17003345DOI10.2337/db05-1315PepBankPUB-17003345

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, rosiglitazone enhanced AICAR-stimulated whole-body glucose disposal by 27% versus vehicle.
In plain wordsIn high-fat-fed rats, rosiglitazone increased AICAR-stimulated glucose disposal compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseAICAR-stimulated glucose disposal
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Measurements
Glucose disposal increase
27%
rosiglitazone versus vehicle
Source sentences
Summary
We found that rosiglitazone treatment significantly enhanced AICAR-stimulated whole-body glucose disposal by 27% in high-fat-fed rats, and a 44% greater glucose infusion rate (both P < 0.01 vs. vehicle control rats) was required to maintain euglycemia.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334501
02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats receiving AICAR, rosiglitazone required a 44% greater glucose infusion rate versus vehicle to maintain euglycemia.
In plain wordsIn high-fat-fed rats receiving AICAR, rosiglitazone increased the glucose infusion needed to maintain normal glucose compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseGlucose infusion rate
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
We found that rosiglitazone treatment significantly enhanced AICAR-stimulated whole-body glucose disposal by 27% in high-fat-fed rats, and a 44% greater glucose infusion rate (both P < 0.01 vs. vehicle control rats) was required to maintain euglycemia.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334502
03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, rosiglitazone enhanced AICAR-stimulated muscle glucose uptake.
In plain wordsIn high-fat-fed rats, rosiglitazone increased AICAR-stimulated muscle glucose uptake compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseMuscle glucose uptake
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Along with this, both AICAR-stimulated glucose uptake and glucose incorporation into glycogen in muscle and adipose tissue were enhanced (P < 0.05).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334503
04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, rosiglitazone enhanced AICAR-stimulated adipose glucose uptake.
In plain wordsIn high-fat-fed rats, rosiglitazone increased AICAR-stimulated glucose uptake in fat tissue compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseAdipose glucose uptake
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Along with this, both AICAR-stimulated glucose uptake and glucose incorporation into glycogen in muscle and adipose tissue were enhanced (P < 0.05).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334504
05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, rosiglitazone enhanced AICAR-stimulated glucose incorporation into muscle glycogen.
In plain wordsIn high-fat-fed rats, rosiglitazone increased AICAR-stimulated glucose storage as muscle glycogen compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseMuscle glycogen incorporation
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Along with this, both AICAR-stimulated glucose uptake and glucose incorporation into glycogen in muscle and adipose tissue were enhanced (P < 0.05).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334505
06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, rosiglitazone enhanced AICAR-stimulated glucose incorporation into adipose glycogen.
In plain wordsIn high-fat-fed rats, rosiglitazone increased AICAR-stimulated glucose storage as glycogen in fat tissue compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseAdipose glycogen incorporation
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
Along with this, both AICAR-stimulated glucose uptake and glucose incorporation into glycogen in muscle and adipose tissue were enhanced (P < 0.05).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334506
07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, enhanced AICAR responses after rosiglitazone were associated with increased total muscle AMPK activity.
In plain wordsIn high-fat-fed rats, rosiglitazone-enhanced AICAR responses were linked to higher total muscle AMPK activity compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseTotal AMPK activity
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
The enhanced glucose uptake and glycogen synthesis in muscle were associated with increased activity of total AMPK and the AMPKalpha2 subunit.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334507
08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, enhanced AICAR responses after rosiglitazone were associated with increased muscle AMPKalpha2 activity.
In plain wordsIn high-fat-fed rats, rosiglitazone-enhanced AICAR responses were linked to higher muscle AMPKalpha2 activity compared with vehicle.
Peptide
AICAR (acadesine)
Outcome
IncreaseAMPKalpha2 activity
Study
ratn: not reported in source
high-fat-fed insulin-resistant rats
Comparator
vehicle control rats
Outcome group
Receptor activity and mechanism · Metabolic and weight
Source sentences
Summary
The enhanced glucose uptake and glycogen synthesis in muscle were associated with increased activity of total AMPK and the AMPKalpha2 subunit.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334508
09AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In standard-diet rats, rosiglitazone did not show the enhancement of AICAR responses observed in high-fat-fed rats.
In plain wordsIn standard-diet rats, rosiglitazone did not show the enhanced AICAR responses seen in high-fat-fed rats.
Peptide
AICAR (acadesine)
Outcome
No significant changeEnhancement of AICAR responses on standard diet
Study
ratn: not reported in source
standard-diet rats
Comparator
vehicle control rats
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
In comparison, these effects were not apparent in rats fed standard rodent diet.
3 context sentences(design, population, supporting numbers)
Summary · context
We found that rosiglitazone treatment significantly enhanced AICAR-stimulated whole-body glucose disposal by 27% in high-fat-fed rats, and a 44% greater glucose infusion rate (both P < 0.01 vs. vehicle control rats) was required to maintain euglycemia.
Summary · context
Along with this, both AICAR-stimulated glucose uptake and glucose incorporation into glycogen in muscle and adipose tissue were enhanced (P < 0.05).
Summary · context
The enhanced glucose uptake and glycogen synthesis in muscle were associated with increased activity of total AMPK and the AMPKalpha2 subunit.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-1700334509

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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