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Study · Not a test of the peptide alone · 2026

4 results

Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells.

Vo HVT, Patton GN, Park JS, Kim SJ, Kim N, Lee HJ

Journal of enzyme inhibition and medicinal chemistry19 Jan 2026Cited by 3 (Europe PMC)

PMID41555543 (opens in a new tab)PMCIDPMC12821374 (opens in a new tab)DOI10.1080/14756366.2026.2616019 (opens in a new tab)PepBankPUB-41555543
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In cancer cells, six exercise mimetics including AICAR reduced MMP-2 expression through STAT3 signaling.

    In plain wordsIn cells, exercise mimetics including AICAR reduced MMP-2 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMMP-2 expression
    Study

    humann: not reported in source

    A549 lung cancer cells and in vitro MMP assays
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    (ii) downregulated MMP-2/9 expression by influencing STAT3 signalling pathways,
    1 context sentence
    Summary · context
    In this study, the possible anti-cancer and anti-metastatic-related effects of six selected exercise mimetics (i.e., AICAR, Icariin, Berberine, Betaine, GW501516, and Metformin) were investigated by targeting activity and/or expression of MMP-2/9 in <…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In cancer cells, six exercise mimetics including AICAR reduced MMP-9 expression through STAT3 signaling.

    In plain wordsIn cells, exercise mimetics including AICAR reduced MMP-9 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMMP-9 expression
    Study

    humann: not reported in source

    A549 lung cancer cells and in vitro MMP assays
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    (ii) downregulated MMP-2/9 expression by influencing STAT3 signalling pathways,
    1 context sentence
    Summary · context
    In this study, the possible anti-cancer and anti-metastatic-related effects of six selected exercise mimetics (i.e., AICAR, Icariin, Berberine, Betaine, GW501516, and Metformin) were investigated by targeting activity and/or expression of MMP-2/9 in <…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Activity measurement

    In A549 lung cancer cells, six exercise mimetics including AICAR reduced viability to varying degrees.

    In plain wordsIn cells, exercise mimetics including AICAR reduced lung cancer cell survival to varying degrees.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseA549 cell viability
    Study

    humann: not reported in source

    A549 lung cancer cells and in vitro MMP assays
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    (iii) reduced lung cancer cells (A549) viability to varying degrees.
    1 context sentence
    Summary · context
    In this study, the possible anti-cancer and anti-metastatic-related effects of six selected exercise mimetics (i.e., AICAR, Icariin, Berberine, Betaine, GW501516, and Metformin) were investigated by targeting activity and/or expression of MMP-2/9 in <…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 04LabNot a test of AICAR (acadesine) aloneIn vitro (cell-free)Mechanism

    In vitro, six exercise mimetics including AICAR inhibited MMP-2 activity through active-site and/or allosteric interactions.

    In plain wordsIn lab tests, exercise mimetics including AICAR inhibited MMP-2 activity.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMMP-2 activity
    Study

    humann: not reported in source

    A549 lung cancer cells and in vitro MMP assays
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    These compounds (i) inhibited MMP-2 activity by interacting with the active site and/or allosteric sites,
    1 context sentence
    Summary · context
    In this study, the possible anti-cancer and anti-metastatic-related effects of six selected exercise mimetics (i.e., AICAR, Icariin, Berberine, Betaine, GW501516, and Metformin) were investigated by targeting activity and/or expression of MMP-2/9 in <…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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