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Study · In vitro (cells) · 2026

2 results

Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis.

Xu Y, Tang J, Wu C, Li R, Zhao Y, Cai M, Tian Z

Journal of cardiovascular translational research7 Aug 2026

PMID42565937 (opens in a new tab)DOI10.1007/s12265-026-10828-x (opens in a new tab)PepBankPUB-42565937
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In H9C2 cells exposed to hypoxia/reoxygenation, AICAR protected against ferroptosis.

    In plain wordsIn cells exposed to low oxygen followed by oxygen restoration, AICAR reduced ferroptosis.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseFerroptosis
    Study

    n: not reported in source

    H9C2 cells subjected to hypoxia/reoxygenation
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AMPK inhibition exacerbated H/R-induced ferroptosis, whereas AMPK activation by AICAR was protective.
    1 context sentence
    Summary · context
    In H9C2 cells, H/R reduced ACC phosphorylation and induced ferroptosis.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In H9C2 cells, blocking ACC enzymatic activity attenuated AICAR's protective effects against ferroptosis.

    In plain wordsIn cells, blocking ACC activity reduced AICAR's protection against ferroptosis.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseACC dependence of AICAR protection
    Study

    n: not reported in source

    H9C2 cells subjected to hypoxia/reoxygenation
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Critically, blocking ACC enzymatic activity attenuated AICAR's effects.
    1 context sentence
    Summary · context
    AMPK inhibition exacerbated H/R-induced ferroptosis, whereas AMPK activation by AICAR was protective.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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