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Study · Not a test of the peptide alone · 2020

3 results

Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness.

Jin K, Ma Y, Manrique-Caballero CL, Li H, Emlet DR, Li S, Baty CJ, Wen X, Kim-Campbell N, Frank A, Menchikova EV, Pastor-Soler NM and 7 more

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Hallows KR, Jackson EK, Shiva S, Pinsky MR, Zuckerbraun BS, Kellum JA, Gómez H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology4 Apr 2020Cited by 69 (Europe PMC)

PMID32246808 (opens in a new tab)PMCIDPMC11956121 (opens in a new tab)DOI10.1096/fj.201901900r (opens in a new tab)PepBankPUB-32246808
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, pharmacologic AMPK activation with AICAR or metformin improved survival.

    In plain wordsIn mice with sepsis, AMPK activation with AICAR or metformin improved survival.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSurvival
    Study

    mousen: not reported in source

    cecal ligation and puncture sepsis
    Outcome group
    Mortality · Whole body

    Source sentences

    Summary
    Pharmacologic activation of AMPK with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) or metformin during sepsis improved the survival,

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02AnimalNot a test of AICAR (acadesine) aloneOther designMechanism

    In the sepsis/inflammation study, AMPK-driven protection was associated with increased Sirt 3 expression, but the model for this result was unspecified.

    In plain wordsIn mice and cells studied for sepsis or inflammation, AMPK-driven protection accompanied increased Sirt 3 expression, without a stated model-specific result.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSirt 3 expression
    Study

    n: not reported in source

    sepsis/inflammation models involving mice and human HK2 cells
    Outcome group
    Receptor activity and mechanism · Kidney and urinary

    Source sentences

    Summary
    AMPK-driven protection was associated with increased Sirt 3 expression and restoration of metabolic fitness.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03AnimalNot a test of AICAR (acadesine) aloneOther designMechanism

    In the sepsis/inflammation study, AMPK-driven protection was associated with restored metabolic fitness, but the model for this result was unspecified.

    In plain wordsIn mice and cells studied for sepsis or inflammation, AMPK-driven protection accompanied restored metabolic fitness, without a stated model-specific result.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMetabolic fitness
    Study

    n: not reported in source

    sepsis/inflammation models involving mice and human HK2 cells
    Outcome group
    Mitochondrial function · Kidney and urinary

    Source sentences

    Summary
    AMPK-driven protection was associated with increased Sirt 3 expression and restoration of metabolic fitness.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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