Electroacupuncture alleviates traumatic brain injury by inhibiting autophagy via increasing IL-10 production and blocking the AMPK/mTOR signaling pathway in rats.

Wu T, Kou J, Li X, Diwu Y, Li Y, Cao DY, Wang R

Metabolic brain disease15 Dec 2022Cited by 13 (Europe PMC)

PMID36517637DOI10.1007/s11011-022-01133-yPepBankPUB-36517637

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with TBI, AICAR reversed electroacupuncture effects on autophagy-related protein levels.
In plain wordsIn rats with brain injury, AICAR reversed electroacupuncture effects on autophagy proteins compared with electroacupuncture alone.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedAutophagy-related protein levels
Study
ratn: not reported in source
Sprague-Dawley rats with traumatic brain injury
Comparator
electroacupuncture without AICAR
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Both AMPK agonist AICAR and IL-10 neutralizing antibody treatments reversed the effects of EA on the related protein levels of autophagy and the AMPK/mTOR signaling pathway, and abolished the protective effects of EA on TBI rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats were randomly divided into three groups: sham, TBI, and TBI + EA. TBI model was established by using an electronic controlled cortical impactor.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3651763701
02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with TBI, AICAR reversed electroacupuncture effects on AMPK/mTOR pathway protein levels.
In plain wordsIn rats with brain injury, AICAR reversed electroacupuncture effects on AMPK/mTOR proteins compared with electroacupuncture alone.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedAMPK/mTOR pathway protein levels
Study
ratn: not reported in source
Sprague-Dawley rats with traumatic brain injury
Comparator
electroacupuncture without AICAR
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Both AMPK agonist AICAR and IL-10 neutralizing antibody treatments reversed the effects of EA on the related protein levels of autophagy and the AMPK/mTOR signaling pathway, and abolished the protective effects of EA on TBI rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats were randomly divided into three groups: sham, TBI, and TBI + EA. TBI model was established by using an electronic controlled cortical impactor.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3651763702
03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism
In rats with TBI, AICAR abolished the protective effects of electroacupuncture.
In plain wordsIn rats with brain injury, AICAR abolished protection from electroacupuncture compared with electroacupuncture alone.
Peptide
AICAR (acadesine)
Outcome
DecreaseElectroacupuncture protection against TBI
Study
ratn: not reported in source
Sprague-Dawley rats with traumatic brain injury
Comparator
electroacupuncture without AICAR
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Both AMPK agonist AICAR and IL-10 neutralizing antibody treatments reversed the effects of EA on the related protein levels of autophagy and the AMPK/mTOR signaling pathway, and abolished the protective effects of EA on TBI rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Sprague-Dawley rats were randomly divided into three groups: sham, TBI, and TBI + EA. TBI model was established by using an electronic controlled cortical impactor.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3651763703

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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