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Study · Not a test of the peptide alone · 2016

5 results

Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway.

Wu YL, Zhang YJ, Yao YL, Li ZM, Han X, Lian LH, Zhao YQ, Nan JX

Toxicology letters27 Jun 2016Cited by 37 (Europe PMC)

PMID27363783 (opens in a new tab)DOI10.1016/j.toxlet.2016.06.2102 (opens in a new tab)PepBankPUB-27363783
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In activated hepatic stellate cells, AICAR showed PI3K phosphorylation inhibition similar to CuE.

    In plain wordsIn cells, AICAR inhibited PI3K phosphorylation, similar to CuE.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePI3K phosphorylation
    Study

    n: not reported in source

    Activated HSC-T6 cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    CuE inhibited PI3K and Akt phosphorylation, and reduced the levels of p-mTOR and p-P70S6K and increased the expression of p-AMPK, which is similar with AICAR and metformin.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In activated hepatic stellate cells, AICAR showed Akt phosphorylation inhibition similar to CuE.

    In plain wordsIn cells, AICAR inhibited Akt phosphorylation, similar to CuE.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAkt phosphorylation
    Study

    n: not reported in source

    Activated HSC-T6 cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    CuE inhibited PI3K and Akt phosphorylation, and reduced the levels of p-mTOR and p-P70S6K and increased the expression of p-AMPK, which is similar with AICAR and metformin.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In activated hepatic stellate cells, AICAR showed reduced phosphorylated mTOR levels similar to CuE.

    In plain wordsIn cells, AICAR reduced phosphorylated mTOR levels, similar to CuE.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePhosphorylated mTOR
    Study

    n: not reported in source

    Activated HSC-T6 cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    CuE inhibited PI3K and Akt phosphorylation, and reduced the levels of p-mTOR and p-P70S6K and increased the expression of p-AMPK, which is similar with AICAR and metformin.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 04LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In activated hepatic stellate cells, AICAR showed reduced phosphorylated P70S6K levels similar to CuE.

    In plain wordsIn cells, AICAR reduced phosphorylated P70S6K levels, similar to CuE.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePhosphorylated P70S6K
    Study

    n: not reported in source

    Activated HSC-T6 cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    CuE inhibited PI3K and Akt phosphorylation, and reduced the levels of p-mTOR and p-P70S6K and increased the expression of p-AMPK, which is similar with AICAR and metformin.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  5. 05LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In activated hepatic stellate cells, AICAR showed increased phosphorylated AMPK expression similar to CuE.

    In plain wordsIn cells, AICAR increased phosphorylated AMPK expression, similar to CuE.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePhosphorylated AMPK expression
    Study

    n: not reported in source

    Activated HSC-T6 cells
    Outcome group
    Receptor activity and mechanism · Liver

    Source sentences

    Summary
    CuE inhibited PI3K and Akt phosphorylation, and reduced the levels of p-mTOR and p-P70S6K and increased the expression of p-AMPK, which is similar with AICAR and metformin.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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