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Study · Not a test of the peptide alone · 2014

6 results

Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

Sun Y, Li J, Xiao N, Wang M, Kou J, Qi L, Huang F, Liu B, Liu K

Pharmacological research7 Aug 2014Cited by 73 (Europe PMC)

PMID25108154 (opens in a new tab)DOI10.1016/j.phrs.2014.07.006 (opens in a new tab)PepBankPUB-25108154
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism

    In rat PVAT, pooled AMPK activators including AICAR inhibited NF-κB p65 phosphorylation.

    In plain wordsIn lab tests, pooled AMPK activators including AICAR reduced inflammatory NF-κB phosphorylation in rat tissue.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNF-κB p65 phosphorylation
    Study

    ratn: not reported in source

    PVAT and aortic tissue
    Comparator
    palmitic acid-stimulated tissue or conditioned medium without activators
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    AMPK activating agents inhibited NF-κB p65 phosphorylation and suppressed gene expression of pro-inflammatory adipocytokines, and upregulated adiponectin and PPARγ expression in PVAT in an AMPK/SIRT1-interdependent manner.
    2 context sentences
    Summary · context
    Thus, in this study, we focused on the regulation of AMPK and SIRT1 activities implicated in adipocytokine expression and endothelial homeostasis under inflammatory conditions by using salicylate, metformin, AICA riboside (AICAR) and resveratrol as AMPK activating agents.
    Summary · context
    We prepared conditioned medium (CM) by stimulating PVAT with palmitic acid (PA) and observed the effects of AMPK activating agents on adipocytokine expression and vessel vasodilation in rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism

    In rat PVAT, pooled AMPK activators including AICAR suppressed pro-inflammatory adipocytokine gene expression.

    In plain wordsIn lab tests, pooled AMPK activators including AICAR reduced inflammatory gene expression in rat tissue.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePro-inflammatory adipocytokine gene expression
    Study

    ratn: not reported in source

    PVAT and aortic tissue
    Comparator
    palmitic acid-stimulated tissue or conditioned medium without activators
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    AMPK activating agents inhibited NF-κB p65 phosphorylation and suppressed gene expression of pro-inflammatory adipocytokines, and upregulated adiponectin and PPARγ expression in PVAT in an AMPK/SIRT1-interdependent manner.
    2 context sentences
    Summary · context
    Thus, in this study, we focused on the regulation of AMPK and SIRT1 activities implicated in adipocytokine expression and endothelial homeostasis under inflammatory conditions by using salicylate, metformin, AICA riboside (AICAR) and resveratrol as AMPK activating agents.
    Summary · context
    We prepared conditioned medium (CM) by stimulating PVAT with palmitic acid (PA) and observed the effects of AMPK activating agents on adipocytokine expression and vessel vasodilation in rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism

    In rat PVAT, pooled AMPK activators including AICAR increased adiponectin expression through interdependent AMPK and SIRT1 activity.

    In plain wordsIn lab tests, pooled AMPK activators including AICAR increased adiponectin expression in rat tissue.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAdiponectin expression
    Study

    ratn: not reported in source

    PVAT and aortic tissue
    Comparator
    palmitic acid-stimulated tissue or conditioned medium without activators
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    AMPK activating agents inhibited NF-κB p65 phosphorylation and suppressed gene expression of pro-inflammatory adipocytokines, and upregulated adiponectin and PPARγ expression in PVAT in an AMPK/SIRT1-interdependent manner.
    2 context sentences
    Summary · context
    Thus, in this study, we focused on the regulation of AMPK and SIRT1 activities implicated in adipocytokine expression and endothelial homeostasis under inflammatory conditions by using salicylate, metformin, AICA riboside (AICAR) and resveratrol as AMPK activating agents.
    Summary · context
    We prepared conditioned medium (CM) by stimulating PVAT with palmitic acid (PA) and observed the effects of AMPK activating agents on adipocytokine expression and vessel vasodilation in rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 04LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism

    In rat PVAT, pooled AMPK activators including AICAR increased PPARγ expression through interdependent AMPK and SIRT1 activity.

    In plain wordsIn lab tests, pooled AMPK activators including AICAR increased PPARγ expression in rat tissue.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePPARγ expression
    Study

    ratn: not reported in source

    PVAT and aortic tissue
    Comparator
    palmitic acid-stimulated tissue or conditioned medium without activators
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    AMPK activating agents inhibited NF-κB p65 phosphorylation and suppressed gene expression of pro-inflammatory adipocytokines, and upregulated adiponectin and PPARγ expression in PVAT in an AMPK/SIRT1-interdependent manner.
    2 context sentences
    Summary · context
    Thus, in this study, we focused on the regulation of AMPK and SIRT1 activities implicated in adipocytokine expression and endothelial homeostasis under inflammatory conditions by using salicylate, metformin, AICA riboside (AICAR) and resveratrol as AMPK activating agents.
    Summary · context
    We prepared conditioned medium (CM) by stimulating PVAT with palmitic acid (PA) and observed the effects of AMPK activating agents on adipocytokine expression and vessel vasodilation in rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  5. 05LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism

    In rat aorta, conditioned medium pretreatment with pooled AMPK activators including AICAR enhanced eNOS phosphorylation.

    In plain wordsIn lab tests, pooled AMPK activators including AICAR increased eNOS phosphorylation in rat aorta.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseeNOS phosphorylation
    Study

    ratn: not reported in source

    PVAT and aortic tissue
    Comparator
    palmitic acid-stimulated tissue or conditioned medium without activators
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Pretreatment of CM with AMPK-activating agents enhanced eNOS phosphorylation in the aorta and restored the loss of endothelium-dependent vasodilation, whereas this action was abolished by co-treatment with AMPK inhibitor compound C or SIRT1 inhibitor nicotinamide.
    2 context sentences
    Summary · context
    Thus, in this study, we focused on the regulation of AMPK and SIRT1 activities implicated in adipocytokine expression and endothelial homeostasis under inflammatory conditions by using salicylate, metformin, AICA riboside (AICAR) and resveratrol as AMPK activating agents.
    Summary · context
    We prepared conditioned medium (CM) by stimulating PVAT with palmitic acid (PA) and observed the effects of AMPK activating agents on adipocytokine expression and vessel vasodilation in rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  6. 06LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism

    In rat vessels, pooled AMPK activators including AICAR restored impaired vasodilation, and AMPK or SIRT1 inhibitors abolished this action.

    In plain wordsIn lab tests, pooled AMPK activators including AICAR restored rat vessel dilation. AMPK or SIRT1 inhibitors blocked this effect.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEndothelium-dependent vasodilation
    Study

    ratn: not reported in source

    PVAT and aortic tissue
    Comparator
    palmitic acid-stimulated tissue or conditioned medium without activators
    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    Pretreatment of CM with AMPK-activating agents enhanced eNOS phosphorylation in the aorta and restored the loss of endothelium-dependent vasodilation, whereas this action was abolished by co-treatment with AMPK inhibitor compound C or SIRT1 inhibitor nicotinamide.
    2 context sentences
    Summary · context
    Thus, in this study, we focused on the regulation of AMPK and SIRT1 activities implicated in adipocytokine expression and endothelial homeostasis under inflammatory conditions by using salicylate, metformin, AICA riboside (AICAR) and resveratrol as AMPK activating agents.
    Summary · context
    We prepared conditioned medium (CM) by stimulating PVAT with palmitic acid (PA) and observed the effects of AMPK activating agents on adipocytokine expression and vessel vasodilation in rats.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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