Ginsenoside Rb1 Ameliorates Autophagy of Hypoxia Cardiomyocytes from Neonatal Rats via AMP-Activated Protein Kinase Pathway.

Dai SN, Hou AJ, Zhao SM, Chen XM, Huang HT, Chen BH, Kong HL

Chinese journal of integrative medicine18 Jul 2018Cited by 12 (Europe PMC)

PMID30088211DOI10.1007/s11655-018-3018-yPepBankPUB-30088211

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect AMPK activity.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change AMPK activity.
Peptide
AICAR (acadesine)
Outcome
No significant changeAMPK activity
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
The AMPK activity of hypoxia-treated cadiomyocytes was inhibited by Ara A (P<0.01) and was not affected by AICAR =0.983).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821101
02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported Atg4B protein response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported Atg4B response.
Peptide
AICAR (acadesine)
Outcome
No significant changeAtg4B protein
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821102
03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported Atg5 protein response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported Atg5 response.
Peptide
AICAR (acadesine)
Outcome
No significant changeAtg5 protein
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821103
04LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported Beclin-1 protein response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported Beclin-1 response.
Peptide
AICAR (acadesine)
Outcome
No significant changeBeclin-1 protein
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821104
05LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported Atg7 protein response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported Atg7 response.
Peptide
AICAR (acadesine)
Outcome
No significant changeAtg7 protein
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821105
06LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported LC3B II protein response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported LC3B II response.
Peptide
AICAR (acadesine)
Outcome
No significant changeLC3B II protein
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821106
07LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported LC3B II/I ratio response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported LC3B II/I ratio response.
Peptide
AICAR (acadesine)
Outcome
No significant changeLC3B II/I ratio
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821107
08LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect the reported cathepsin B activity response.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change the reported cathepsin B activity response.
Peptide
AICAR (acadesine)
Outcome
No significant changeCathepsin B activity
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Gs-Rb1 up-regulated Atg4B, Atg5, Beclin-1, Atg7, LC3B II, the LC3B II/I ratio and cathepsin B activity of hypoxia cardiomyocytes (P0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821108
09LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In hypoxic rat cardiomyocytes, AICAR did not affect P62 levels.
In plain wordsIn cells from rat hearts under hypoxia, AICAR did not change P62 levels.
Peptide
AICAR (acadesine)
Outcome
No significant changeP62 protein
Study
ratn: not reported in source
Hypoxic neonatal rat cardiomyocytes
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
The P62 levels of hypoxic cardiomyocytes were inhibited by Ara A (P<0.05) and were not affected by AICAR (P=0.871).
1 context sentence(design, population, supporting numbers)
Summary · context
Cells were treated for 12 h and cell viability was determined by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and cardiac troponin I (cTnI) levels were detected by enzyme-linked immunosorbent assay (ELISA).
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-3008821109

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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