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Study · In vitro (cells) · 2026

1 result

FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis.

Mao L, Dang D, Wang W

Biochemical and biophysical research communications6 Aug 2026

PMID42570491 (opens in a new tab)DOI10.1016/j.bbrc.2026.154403 (opens in a new tab)PepBankPUB-42570491
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In LPS-treated H9C2 cells, AICAR mimicked the protective effects of FGF21.

    In plain wordsIn cells treated with LPS, AICAR produced protective effects similar to those of FGF21.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedProtective effects mimicking FGF21
    Study

    n: not reported in source

    LPS-treated H9C2 cells
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The AMPK agonist AICAR mimicked, while the AMPK antagonist Compound C partially reversed, the protective effects of FGF21.
    1 context sentence
    Summary · context
    In LPS-treated H9C2 cells, FGF21 overexpression reversed the LPS-induced decline in mitochondrial function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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