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Study · Other design · 2021

1 result

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.

Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP and 4 more

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O'Donnell CP, Finkel T, Chen BB, Mallampalli RK

Nature chemical biology25 Jan 2021Cited by 36 (Europe PMC)

PMID33495648 (opens in a new tab)PMCIDPMC8529588 (opens in a new tab)DOI10.1038/s41589-020-00723-0 (opens in a new tab)PepBankPUB-33495648
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabOther designActivity measurement

    In experimental assays, AICAR had lower potency than BC1618 in stimulating AMPK-dependent signaling.

    In plain wordsIn lab tests, AICAR stimulated AMPK signaling less potently than BC1618.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePotency in stimulating AMPK-dependent signaling
    Study

    n: not reported in source

    Comparator
    BC1618
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We have generated a novel Fbxo48 inhibitory compound, BC1618, whose potency in stimulating Ampk-dependent signaling greatly exceeds 5-aminoimidazole-4-carboxamide-1-β-ribofuranoside (AICAR) or metformin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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