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Study · Not a test of the peptide alone · 2012

4 results

Microarray expression analysis in delayed cardioprotection: the effect of exercise, AICAR, or metformin and the possible role of AMP-activated protein kinase (AMPK).

Solskov L, Magnusson NE, Kristiansen SB, Jessen N, Nielsen TT, Schmitz O, Bøtker HE, Lund S

Molecular and cellular biochemistry1 Oct 2011Cited by 16 (Europe PMC)

PMID21964537 (opens in a new tab)DOI10.1007/s11010-011-1075-z (opens in a new tab)PepBankPUB-21964537
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01Computer modelNot a test of AICAR (acadesine) aloneIn silicoMechanism

    In rat ventricular microarray analysis, the AICAR group had 304 genes with expression altered more than 2.0-fold.

    In plain wordsIn computer analysis of rat heart tissue, AICAR exposure was linked to 304 genes with altered expression.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedAltered gene count
    Study

    ratn: not reported in source

    left ventricular gene-expression analysis
    Outcome group
    Gene expression · Cardiovascular

    Measurements

    Altered genes
    304 genes
    AICAR group

    Source sentences

    Summary
    A total of 147, 304, and 114 different genes in the left ventricle whose expressions were altered >2.0-fold were identified in the exercise, AICAR, and metformin group, respectively.
    1 context sentence
    Summary · context
    Rats were divided into either an exercise, AICAR, metformin, or control group.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02Computer modelNot a test of AICAR (acadesine) aloneIn silicoMechanism

    In rat ventricular analysis, exercise and AICAR groups shared seventy eight altered genes at 24 h.

    In plain wordsIn computer analysis of rat heart tissue, exercise and AICAR groups shared seventy eight altered genes.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedExercise-AICAR overlapping genes
    Study

    ratn: not reported in source

    left ventricular gene-expression analysis
    Outcome group
    Gene expression · Cardiovascular

    Source sentences

    Summary
    Seventy eight different genes were overlapping the exercise and AICAR group at 24 h.
    1 context sentence
    Summary · context
    Rats were divided into either an exercise, AICAR, metformin, or control group.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03Computer modelNot a test of AICAR (acadesine) aloneIn silicoMechanism

    In rat ventricular pathway analysis, exercise, AICAR and metformin groups shared six genes.

    In plain wordsIn computer analysis of rat heart tissue, exercise, AICAR and metformin groups shared six genes.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedThree-intervention overlapping genes
    Study

    ratn: not reported in source

    left ventricular gene-expression analysis
    Outcome group
    Gene expression · Cardiovascular

    Source sentences

    Summary
    Ingenuity identified six overlapping genes between the exercise, AICAR, and metformin groups including NR4A3, TNFRSF12A, HBB, PENK, PAP, and MAP4K4.
    1 context sentence
    Summary · context
    Rats were divided into either an exercise, AICAR, metformin, or control group.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 04Computer modelNot a test of AICAR (acadesine) aloneIn silicoMechanism

    In rat ventricular pathway analysis, all intervention groups showed enrichment related to cell death, proliferation, gene expression and cancer.

    In plain wordsIn computer analysis of rat heart tissue, all intervention groups showed enrichment for cell death, growth, proliferation, gene expression and cancer.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedFunctional enrichment
    Study

    ratn: not reported in source

    left ventricular gene-expression analysis
    Outcome group
    Gene expression · Cardiovascular

    Source sentences

    Summary
    IPA software revealed an overabundance of focus molecules in all three intervention groups involving functions related to cell death, cellular growth and proliferation, gene expression and cancer.
    1 context sentence
    Summary · context
    Rats were divided into either an exercise, AICAR, metformin, or control group.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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