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Study · Not a test of the peptide alone · 2018

3 results

A curcumin derivative J147 ameliorates diabetic peripheral neuropathy in streptozotocin (STZ)-induced DPN rat models through negative regulation AMPK on TRPA1.

Lv J, Cao L, Zhang R, Bai F, Wei P

Acta cirurgica brasileira1 Jun 2018Cited by 21 (Europe PMC)

PMID30020315 (opens in a new tab)DOI10.1590/s0102-865020180060000008 (opens in a new tab)PepBankPUB-30020315
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In RSC96 cells studied using AICAR, AMPK negatively regulated TRPA1 expression.

    In plain wordsIn cells studied using AICAR, AMPK negatively regulated TRPA1 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTRPA1 expression
    Study

    n: not reported in source

    AICAR-treated RSC96 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Besides, AMPK negative regulated TRPA1 expression in RSC96 cells.
    1 context sentence
    Summary · context
    Then, TRPA1 expression level and calcium reaction level were assessed in agonist AICAR treated RSC96cells.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In AICAR-treated RSC96 cells, J147 reduced TRPA1 expression.

    In plain wordsIn cells treated with AICAR, J147 reduced TRPA1 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTRPA1 expression after J147 treatment
    Study

    n: not reported in source

    AICAR-treated RSC96 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The results showed that J147reduced MWT in vivo, increased the mRNA and protein level of AMPK, reduced TRPA1 expression and calcium reaction level in AITCR treated RSC96 cells, and had no obvious effect on cell viability and apoptosis.
    1 context sentence
    Summary · context
    Then, TRPA1 expression level and calcium reaction level were assessed in agonist AICAR treated RSC96cells.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In AICAR-treated RSC96 cells, J147 reduced the calcium reaction level.

    In plain wordsIn cells treated with AICAR, J147 reduced the calcium response.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCalcium reaction after J147 treatment
    Study

    n: not reported in source

    AICAR-treated RSC96 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The results showed that J147reduced MWT in vivo, increased the mRNA and protein level of AMPK, reduced TRPA1 expression and calcium reaction level in AITCR treated RSC96 cells, and had no obvious effect on cell viability and apoptosis.
    1 context sentence
    Summary · context
    Then, TRPA1 expression level and calcium reaction level were assessed in agonist AICAR treated RSC96cells.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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