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Study · In vitro (cells) · 2025

2 results

Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis.

Liu Z, Yang Y, Song L, Ruan X, Li X, He Y, Zou Y, Ding S, Sun Y

Journal of innate immunity27 Sept 2025Cited by 2 (Europe PMC)

PMID41036663 (opens in a new tab)PMCIDPMC12659644 (opens in a new tab)DOI10.1159/000548603 (opens in a new tab)PepBankPUB-41036663
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In H9C2 cells, AICAR inhibited NLRP3 inflammasome activation through P2X4, sharing a mechanism with exercise.

    In plain wordsIn cells, AICAR inhibited inflammasome activation through P2X4, sharing a mechanism with exercise.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNLRP3 inflammasome activation through P2X4
    Study

    n: not reported in source

    H9C2 cardiomyocytes
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exercise and AICAR share a common mechanism in inhibiting NLRP3 inflammasome activation through P2X4, while AICAR exhibits a partial effect on P2X7 compared with exercise.
    2 context sentences
    Summary · context
    In vitro, H9C2 cardiomyocytes were exposed to high glucose or palmitic acid to mimic diabetic condition.
    Summary · context
    The AMPK agonist AICAR was applied to H9C2 cells to reproduce the molecular effects of exercise.
  2. 02LabIn vitro (cells)Mechanism

    In H9C2 cells, AICAR had a partial effect on P2X7 compared with exercise.

    In plain wordsIn cells, AICAR had a partial effect on P2X7 compared with exercise.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedEffect on P2X7
    Study

    n: not reported in source

    H9C2 cardiomyocytes
    Comparator
    Exercise
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exercise and AICAR share a common mechanism in inhibiting NLRP3 inflammasome activation through P2X4, while AICAR exhibits a partial effect on P2X7 compared with exercise.
    2 context sentences
    Summary · context
    In vitro, H9C2 cardiomyocytes were exposed to high glucose or palmitic acid to mimic diabetic condition.
    Summary · context
    The AMPK agonist AICAR was applied to H9C2 cells to reproduce the molecular effects of exercise.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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