Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women.

Liong S, Lappas M

Journal of physiology and biochemistry25 Sept 2015Cited by 38 (Europe PMC)

PMID26407807DOI10.1007/s13105-015-0435-7PepBankPUB-26407807

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's tissues, AICAR or phenformin suppressed LPS- or IL-1β-induced IL-6 gene expression.
In plain wordsIn lab tests, AICAR or phenformin suppressed inflammation-induced IL-6 gene expression in tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseIL-6 gene expression
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6,
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780701
02LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's tissues, AICAR or phenformin suppressed LPS- or IL-1β-induced IL-8 gene expression.
In plain wordsIn lab tests, AICAR or phenformin suppressed inflammation-induced IL-8 gene expression in tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseIL-8 gene expression
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780702
03LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's tissues, AICAR or phenformin suppressed LPS- or IL-1β-induced MCP-1 gene expression.
In plain wordsIn lab tests, AICAR or phenformin suppressed inflammation-induced MCP-1 gene expression in tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseMCP-1 gene expression
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780703
04LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's tissues, AICAR or phenformin suppressed induced COX-2.
In plain wordsIn lab tests, AICAR or phenformin suppressed induced COX-2 in tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseCOX-2
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780704
05LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's tissues, AICAR or phenformin suppressed induced prostaglandin release.
In plain wordsIn lab tests, AICAR or phenformin reduced induced prostaglandin release in tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseProstaglandin release
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780705
06LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's skeletal muscle, AMPK activators decreased LPS- or IL-1β-induced insulin resistance.
In plain wordsIn lab tests, AMPK activators reduced induced insulin resistance in muscle samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseInsulin resistance
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
In addition, activators of AMPK decreased skeletal muscle insulin resistance induced by LPS or IL-1β as evidenced by increased insulin-stimulated phosphorylation of IRS-1, GLUT-4 expression and glucose uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780706
07LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's skeletal muscle, AMPK activators increased insulin-stimulated IRS-1 phosphorylation after inflammatory challenge.
In plain wordsIn lab tests, AMPK activators increased insulin-stimulated IRS-1 phosphorylation in muscle samples.
Peptide
AICAR (acadesine)
Outcome
IncreaseIRS-1 phosphorylation
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
In addition, activators of AMPK decreased skeletal muscle insulin resistance induced by LPS or IL-1β as evidenced by increased insulin-stimulated phosphorylation of IRS-1, GLUT-4 expression and glucose uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780707
08LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's skeletal muscle, AMPK activators increased GLUT-4 expression after inflammatory challenge.
In plain wordsIn lab tests, AMPK activators increased GLUT-4 expression in muscle samples.
Peptide
AICAR (acadesine)
Outcome
IncreaseGLUT-4 expression
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
In addition, activators of AMPK decreased skeletal muscle insulin resistance induced by LPS or IL-1β as evidenced by increased insulin-stimulated phosphorylation of IRS-1, GLUT-4 expression and glucose uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780708
09LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's skeletal muscle, AMPK activators increased glucose uptake after inflammatory challenge.
In plain wordsIn lab tests, AMPK activators increased glucose uptake in muscle samples.
Peptide
AICAR (acadesine)
Outcome
IncreaseGlucose uptake
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
In addition, activators of AMPK decreased skeletal muscle insulin resistance induced by LPS or IL-1β as evidenced by increased insulin-stimulated phosphorylation of IRS-1, GLUT-4 expression and glucose uptake.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus, the aims of this study were (i) to compare the expression of AMPK in adipose tissue and skeletal muscle from women with GDM and normal glucose-tolerant (NGT) pregnant women;
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780709
10LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's adipose tissue and skeletal muscle, AICAR or phenformin suppressed LPS- or IL-1β-induced IL-6 secretion.
In plain wordsIn lab tests, AICAR or phenformin suppressed inflammation-induced IL-6 secretion from tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseIL-6 secretion
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780710
11LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's adipose tissue and skeletal muscle, AICAR or phenformin suppressed LPS- or IL-1β-induced IL-8 secretion.
In plain wordsIn lab tests, AICAR or phenformin suppressed inflammation-induced IL-8 secretion from tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseIL-8 secretion
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780711
12LabNot a test of AICAR (acadesine) aloneEx vivo tissueMechanism
In pregnant women's adipose tissue and skeletal muscle, AICAR or phenformin suppressed LPS- or IL-1β-induced MCP-1 secretion.
In plain wordsIn lab tests, AICAR or phenformin suppressed inflammation-induced MCP-1 secretion from tissue samples.
Peptide
AICAR (acadesine)
Outcome
DecreaseMCP-1 secretion
Study
humann: not reported in source
adipose tissue and skeletal muscle from pregnant women
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1β-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2640780712

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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