In islets and beta cells, medium from AICAR-treated muscle cells reduced cytokine-induced cell death by 38%.
In plain wordsIn lab tests, medium from AICAR-treated muscle cells reduced cytokine-induced beta-cell death.
- Peptide
- AICAR (acadesine)
- Outcome
- DecreaseCytokine-induced beta-cell death
- Study
mouse and ratn: not reported in source
Pancreatic islets and INS-1E and MIN6 cells- Outcome group
- Cell viability and death · Metabolic and weight
Measurements
- Cell death reduction
- 38%
- medium from AICAR-treated C2C12 cells
Source sentences
Serum from trained mice and medium from AICAR-treated C2C12 cells reduced β-cell death, induced by IL-1β plus IFN-γ treatment, in 15 and 38%, respectively.
2 context sentences(design, population, supporting numbers)
Islets from control mice and β-cell lines (INS-1E and MIN6) were incubated with serum from control or trained mice or medium obtained from 5-aminoimidazole-4 carboxamide1-β-d-ribofuranoside (AICAR)-treated C2C12 skeletal muscle cells.
Subsequently, islets and β cells were exposed to IL-1β plus IFN-γ.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).