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Study · In vitro (cells) · 2015

4 results

DNA aneuploidy-specific therapy for head and neck squamous cell carcinoma.

García Martínez J, García-Inclán C, Suárez C, Llorente JL, Hermsen MA

Head & neck27 Jun 2014Cited by 5 (Europe PMC)

PMID24623685 (opens in a new tab)DOI10.1002/hed.23687 (opens in a new tab)PepBankPUB-24623685
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cell cultures, AICAR inhibited aneuploid HNSCC cell growth more than diploid HNSCC cell growth.

    In plain wordsIn cells, AICAR inhibited growth more in aneuploid than diploid head and neck cancer cells.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCell growth versus diploid HNSCC cells
    Study

    humann: not reported in source

    HNSCC cell lines
    Comparator
    Diploid HNSCC cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A significant growth inhibitory effect by both compounds was observed in the aneuploid compared to diploid HNSCC cell lines and to the normal keratinocytes.
    1 context sentence
    Summary · context
    Two such compounds, 5-aminoimidazole-4-carboxamide riboside (AICAR) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), were tested using a panel of stable diploid and unstable aneuploid HNSCC cell lines, and short-term cultures of normal keratinocytes as control.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cell cultures, AICAR inhibited aneuploid HNSCC cell growth more than normal keratinocyte growth.

    In plain wordsIn cells, AICAR inhibited aneuploid head and neck cancer growth more than normal keratinocyte growth.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCell growth versus normal keratinocytes
    Study

    humann: not reported in source

    HNSCC cell lines
    Comparator
    Normal keratinocytes
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A significant growth inhibitory effect by both compounds was observed in the aneuploid compared to diploid HNSCC cell lines and to the normal keratinocytes.
    1 context sentence
    Summary · context
    Two such compounds, 5-aminoimidazole-4-carboxamide riboside (AICAR) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), were tested using a panel of stable diploid and unstable aneuploid HNSCC cell lines, and short-term cultures of normal keratinocytes as control.
  3. 03LabIn vitro (cells)Efficacy outcome

    In HNSCC cell cultures, AICAR growth inhibition was independent of TP53 mutation status.

    In plain wordsIn cells, AICAR growth inhibition did not depend on TP53 mutation status.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeTP53 dependence of growth inhibition
    Study

    humann: not reported in source

    HNSCC cell lines
    Comparator
    Different TP53 mutation status
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This effect was independent from the TP53 mutation status.
    2 context sentences
    Summary · context
    A significant growth inhibitory effect by both compounds was observed in the aneuploid compared to diploid HNSCC cell lines and to the normal keratinocytes.
    Summary · context
    Two such compounds, 5-aminoimidazole-4-carboxamide riboside (AICAR) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), were tested using a panel of stable diploid and unstable aneuploid HNSCC cell lines, and short-term cultures of normal keratinocytes as control.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 04LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Efficacy outcome

    In HNSCC cell cultures, combined AICAR and 17-AAG treatment produced the strongest growth inhibition.

    In plain wordsIn cells, AICAR with 17-AAG produced the strongest growth inhibition.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCombination growth inhibition
    Study

    humann: not reported in source

    HNSCC cell lines
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Combination treatment with AICAR and 17-AAG demonstrated the strongest inhibition.
    1 context sentence
    Summary · context
    Two such compounds, 5-aminoimidazole-4-carboxamide riboside (AICAR) and 17-allylamino-17-demethoxygeldanamycin (17-AAG), were tested using a panel of stable diploid and unstable aneuploid HNSCC cell lines, and short-term cultures of normal keratinocytes as control.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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