Skip to content

Study · Measured the body's own peptide · 2025

5 results

Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase.

Huimin C, Shufen P, Zhaoyu C, Jiaxin L, Li C, Xingzhu Y, Bangfu W, Ying Z, Yu W, Li M, Chanhua L, Dongyan L and 5 more

Show all authors

Bichao X, Yanyan L, Ping Y, Chao G, Yuhan T

Food research international (Ottawa, Ont.)29 Aug 2025Cited by 1 (Europe PMC)

PMID41215006 (opens in a new tab)DOI10.1016/j.foodres.2025.117392 (opens in a new tab)PepBankPUB-41215006
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    Under quercetin treatment, endogenous AICAR was the most prominently altered purine intermediate, without a reported direction.

    In plain wordsIn mice, quercetin altered natural AICAR levels most prominently among the reported purine intermediates, without a reported direction.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedAICAR alteration with quercetin
    Study

    mousen: not reported in source

    ethanol-fed mice treated with quercetin
    Outcome group
    Metabolic pathways and metabolomics · Liver

    Measurements

    VIP
    4.237 score
    AICAR under quercetin treatment

    Source sentences

    Summary
    Notably, the purine intermediate 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) was identified as the most prominently altered one under quercetin treatment (VIP = 4.237, P < 0.05).
    2 context sentences
    Summary · context
    Initially, mice fed a Lieber-DeCarli diet containing 5 % (v/v) ethanol and quercetin (100 mg/kg·bw) exhibited decreased triglyceride level, serum aminotransferase concentration, and hepatic lipid droplet accumulation.
    Summary · context
    Additionally, integrated analysis of transcriptomic and metabolomic revealed significant enrichment in purine metabolic pathway, which supplies substrates for the S-phase of the cell cycle.

    This result measures the body's own AICAR (acadesine). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hepatocytes, adding AICAR to quercetin increased senescence-associated β-galactosidase-positive cells and abrogated quercetin's anti-senescent effect.

    In plain wordsIn cells, AICAR with quercetin increased cells with a senescence marker and blocked quercetin's protective effect.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSA-β-gal-positive cells
    Study

    n: not reported in source

    hepatocytes
    Outcome group
    Aging markers · Liver

    Source sentences

    Summary
    AICAR administration abrogated the anti-senescent effects of quercetin in hepatocytes, evidenced by increased SA-β-gal+ cells and elevated senescent marker (p53, p21, and p16) expression.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 03LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hepatocytes, AICAR with quercetin elevated the senescence marker p53 and abrogated quercetin's anti-senescent effect.

    In plain wordsIn cells, AICAR with quercetin increased p53 expression and blocked quercetin's protective effect.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep53 expression
    Study

    n: not reported in source

    hepatocytes
    Outcome group
    Aging markers · Liver

    Source sentences

    Summary
    AICAR administration abrogated the anti-senescent effects of quercetin in hepatocytes, evidenced by increased SA-β-gal+ cells and elevated senescent marker (p53, p21, and p16) expression.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 04LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hepatocytes, AICAR with quercetin elevated the senescence marker p21 and abrogated quercetin's anti-senescent effect.

    In plain wordsIn cells, AICAR with quercetin increased p21 expression and blocked quercetin's protective effect.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep21 expression
    Study

    n: not reported in source

    hepatocytes
    Outcome group
    Aging markers · Liver

    Source sentences

    Summary
    AICAR administration abrogated the anti-senescent effects of quercetin in hepatocytes, evidenced by increased SA-β-gal+ cells and elevated senescent marker (p53, p21, and p16) expression.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 05LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hepatocytes, AICAR with quercetin elevated the senescence marker p16 and abrogated quercetin's anti-senescent effect.

    In plain wordsIn cells, AICAR with quercetin increased p16 expression and blocked quercetin's protective effect.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep16 expression
    Study

    n: not reported in source

    hepatocytes
    Outcome group
    Aging markers · Liver

    Source sentences

    Summary
    AICAR administration abrogated the anti-senescent effects of quercetin in hepatocytes, evidenced by increased SA-β-gal+ cells and elevated senescent marker (p53, p21, and p16) expression.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.