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Study · In vitro (cells) · rat · 2018

8 results

[Rosuvastatin protects acute myocardial infarction rats through autophagy regulation via AMPK signaling].

Song ZC, Chen L, Zhang D, Zhang SY, Lin X

Zhonghua yi xue za zhi1 Nov 2018Cited by 9 (Europe PMC)

PMID30481906 (opens in a new tab)DOI10.3760/cma.j.issn.0376-2491.2018.43.015 (opens in a new tab)PepBankPUB-30481906
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR increased Beclin1 mRNA, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR increased Beclin1 mRNA compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBeclin1 mRNA
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  2. 02LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR increased Beclin1 protein, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR increased Beclin1 protein compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBeclin1 protein
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  3. 03LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR increased Bcl-2 mRNA, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR increased Bcl-2 mRNA compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBcl-2 mRNA
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  4. 04LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR increased Bcl-2 protein, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR increased Bcl-2 protein compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBcl-2 protein
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  5. 05LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR decreased p62 mRNA, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR decreased p62 mRNA compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    Decreasep62 mRNA
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  6. 06LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR decreased p62 protein, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR decreased p62 protein compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    Decreasep62 protein
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  7. 07LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR decreased BAX mRNA, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR decreased BAX mRNA compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBAX mRNA
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.
  8. 08LabIn vitro (cells)Mechanism

    In hypoxic H9c2 cells, AICAR decreased BAX protein, consistent with the rosuvastatin response.

    In plain wordsIn cells, AICAR decreased BAX protein compared with the hypoxia group.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBAX protein
    Study

    ratn: not reported in source

    Hypoxic H9c2 myocardial cells
    Comparator
    Hypoxia group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The above changes were consistent with those of the AMPK activator group and were antagonized by Compound C.
    2 context sentences
    Summary · context
    In vitro experiments showed that, after RSV intervening, the levels of Beclin1 and Bcl-2 mRNA and protein in the myocardial cells of Hypoxia group significantly increased in triple, while the expressions of p62 and BAX mRNA and protein significantly decreased above a half.
    Summary · context
    Rat myocardial cell line H9c2 was divided into control group, Hypoxia group, Hypoxia+ RSV group, Hypoxia+ RSV+ Compound C group, Hypoxia+ AICAR (AMPK activator)group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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Publication types

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