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Study · In vitro (cells) · bovine · 2025

1 result

AMP-activated protein kinase-Caspase 6 axis regulation alleviates the combined apoptotic damage caused by deoxynivalenol and fumonisin B1 in mammary glands.

Cao L, Li G, Liu K, Gao W, Dong Y, Yang Z, Luo J, Lei L, Du X, Song Y, Li X, Gao W, Liu G

NPJ science of food25 Nov 2025

PMID41290726 (opens in a new tab)PMCIDPMC12669614 (opens in a new tab)DOI10.1038/s41538-025-00574-w (opens in a new tab)PepBankPUB-41290726
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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In bovine mammary epithelial cells exposed to combined mycotoxins, AMPK activation with AICAR alleviated apoptosis.

    In plain wordsIn cells exposed to combined mycotoxins, AICAR reduced cell death.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseApoptosis
    Study

    bovinen: not reported in source

    bovine mammary epithelial cells exposed to DON and FB1
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Silencing Caspase 6 via siRNA, inhibiting with Z-VEID-FMK, or activating AMPK with AICAR alleviated apoptosis.
    1 context sentence
    Summary · context
    This study investigates combined toxic effects of DON and FB1 on bovine mammary epithelial cells (BMECs), and role of AMPK-Caspase 6 axis in mycotoxin-induced apoptosis in BMECs and mouse model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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