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Study · In vitro (cells) · 2025

3 results

Mechanisms of aerobic exercise on doxorubicin-induced cardiomyocyte apoptosis: based on AMPK/PI3K/AKT signalling pathway.

Zhao Q, Zhao X, Zhang X, Cong R, Chen X, Dong D, Sun M

Life sciences20 May 2025Cited by 1 (Europe PMC)

PMID40404115 (opens in a new tab)DOI10.1016/j.lfs.2025.123731 (opens in a new tab)PepBankPUB-40404115
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In H9c2 cells, AICAR reduced Dox-induced cardiomyocyte apoptosis.

    In plain wordsIn cells, AICAR reduced cell death compared with Dox injury.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardiomyocyte apoptosis
    Study

    n: not reported in source

    Dox-injured H9c2 cells
    Comparator
    Dox injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, the AICAR reduced Dox-induced cardiomyocyte apoptosis and promoted cardiomyocyte proliferation by activating the PI3K/AKT signalling pathway.
    1 context sentence
    Summary · context
    In addition, an in vitro model of Dox-induced cardiomyocyte injury was established by using H9c2 cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In H9c2 cells, AICAR promoted cardiomyocyte proliferation during Dox injury.

    In plain wordsIn cells, AICAR increased cell multiplication compared with Dox injury.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCardiomyocyte proliferation
    Study

    n: not reported in source

    Dox-injured H9c2 cells
    Comparator
    Dox injury
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, the AICAR reduced Dox-induced cardiomyocyte apoptosis and promoted cardiomyocyte proliferation by activating the PI3K/AKT signalling pathway.
    1 context sentence
    Summary · context
    In addition, an in vitro model of Dox-induced cardiomyocyte injury was established by using H9c2 cells.
  3. 03LabIn vitro (cells)Mechanism

    In H9c2 cells, AICAR activated the PI3K/AKT signaling pathway during Dox injury.

    In plain wordsIn cells, AICAR activated the PI3K/AKT pathway compared with Dox injury.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePI3K/AKT pathway activation
    Study

    n: not reported in source

    Dox-injured H9c2 cells
    Comparator
    Dox injury
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, the AICAR reduced Dox-induced cardiomyocyte apoptosis and promoted cardiomyocyte proliferation by activating the PI3K/AKT signalling pathway.
    1 context sentence
    Summary · context
    In addition, an in vitro model of Dox-induced cardiomyocyte injury was established by using H9c2 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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