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Study · Animal study (in vivo) · rat · 2024

2 results

Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway.

Bo C, Liu F, Zhang Z, Du Z, Xiu H, Zhang Z, Li M, Zhang C, Jia Q

BMC pulmonary medicine8 May 2024Cited by 12 (Europe PMC)

PMID38720270 (opens in a new tab)PMCIDPMC11080310 (opens in a new tab)DOI10.1186/s12890-024-03014-9 (opens in a new tab)PepBankPUB-38720270
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Summary

BackgroundSimvastatin (Sim), a hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has been widely used in prevention and treatment of cardiovascular diseases. Studies have suggested that Sim exerts anti-fibrotic effects by interfering fibroblast proliferation and collagen synthesis. This study was to determine whether Sim could alleviate silica-induced pulmonary fibrosis and explore the underlying mechanisms.MethodsThe rat model of silicosis was established by the tracheal perfusion method and treated with Sim (5 or 10 mg/kg), AICAR (an AMPK agonist), and apocynin (a NOX inhibitor) for 28 days. Lung tissues were collected for further analyses including pathological histology, inflammatory response, oxidative stress, epithelial mesenchymal transformation (EMT), and the AMPK-NOX pathway.ResultsSim significantly reduced silica-induced pulmonary inflammation and fibrosis at 28 days after administration. Sim could reduce the levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α and transforming growth factor-β1 in lung tissues. The expressions of hydroxyproline, α-SMA and vimentin were down-regulated, while E-cad was increased in Sim-treated rats. In addition, NOX4, p22pox, p40phox, p-p47phox/p47phox expressions and ROS levels were all increased, whereas p-AMPK/AMPK was decreased in silica-induced rats. Sim or AICAR treatment could notably reverse the decrease of AMPK activity and increase of NOX activity induced by silica. Apocynin treatment exhibited similar protective effects to Sim, including down-regulating of oxidative stress and inhibition of the EMT process and inflammatory reactions.ConclusionsSim attenuates silica-induced pulmonary inflammation and fibrosis by downregulating EMT and oxidative stress through the AMPK-NOX pathway.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In silica-exposed rats, AICAR reversed the reduction in AMPK activity.

    In plain wordsIn rats exposed to silica, AICAR restored reduced AMPK activity.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK activity
    Study

    ratn: not reported in source

    Silica-induced pulmonary fibrosis
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Sim or AICAR treatment could notably reverse the decrease of AMPK activity and increase of NOX activity induced by silica.
    1 context sentence
    Summary · context
    The rat model of silicosis was established by the tracheal perfusion method and treated with Sim (5 or 10 mg/kg), AICAR (an AMPK agonist), and apocynin (a NOX inhibitor) for 28 days.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In silica-exposed rats, AICAR reversed the increase in NOX activity.

    In plain wordsIn rats exposed to silica, AICAR reduced elevated NOX activity.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNOX activity
    Study

    ratn: not reported in source

    Silica-induced pulmonary fibrosis
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Sim or AICAR treatment could notably reverse the decrease of AMPK activity and increase of NOX activity induced by silica.
    1 context sentence
    Summary · context
    The rat model of silicosis was established by the tracheal perfusion method and treated with Sim (5 or 10 mg/kg), AICAR (an AMPK agonist), and apocynin (a NOX inhibitor) for 28 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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