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Study · Animal study (in vivo) · rat · 2015

4 results

A comparison of chronic AICAR treatment-induced metabolic adaptations in red and white muscles of rats.

Suwa M, Nakano H, Radak Z, Kumagai S

The journal of physiological sciences : JPS12 Nov 2014Cited by 6 (Europe PMC)

PMID25388945 (opens in a new tab)PMCIDPMC10717678 (opens in a new tab)DOI10.1007/s12576-014-0349-0 (opens in a new tab)PepBankPUB-25388945
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased NAMPT expression, with reported adaptations more prominent in or confined to white gastrocnemius.

    In plain wordsIn rats, AICAR increased NAMPT expression, with stronger or exclusive adaptations in white muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseNAMPT expression
    Study

    ratn: not reported in source

    Red and white gastrocnemius muscle
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    1 mg/g body weight/day · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Rats were treated with AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), glucose transporter 4 proteins, and enhanced mitochondrial biogenesis.
    1 context sentence
    Summary · context
    These changes were more prominent in white rather than red gastrocnemius muscle or were only observed in the white gastrocnemius.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased PGC-1α expression, with reported adaptations more prominent in or confined to white gastrocnemius.

    In plain wordsIn rats, AICAR increased PGC-1α expression, with stronger or exclusive adaptations in white muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePGC-1α expression
    Study

    ratn: not reported in source

    Red and white gastrocnemius muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    1 mg/g body weight/day · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Rats were treated with AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), glucose transporter 4 proteins, and enhanced mitochondrial biogenesis.
    1 context sentence
    Summary · context
    These changes were more prominent in white rather than red gastrocnemius muscle or were only observed in the white gastrocnemius.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR increased glucose transporter 4 protein expression, with adaptations more prominent in or confined to white gastrocnemius.

    In plain wordsIn rats, AICAR increased glucose transporter 4 proteins, with stronger or exclusive adaptations in white muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGlucose transporter 4 protein expression
    Study

    ratn: not reported in source

    Red and white gastrocnemius muscle
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    1 mg/g body weight/day · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Rats were treated with AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), glucose transporter 4 proteins, and enhanced mitochondrial biogenesis.
    1 context sentence
    Summary · context
    These changes were more prominent in white rather than red gastrocnemius muscle or were only observed in the white gastrocnemius.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR enhanced mitochondrial biogenesis, with reported adaptations more prominent in or confined to white gastrocnemius.

    In plain wordsIn rats, AICAR increased mitochondrial production, with stronger or exclusive adaptations in white muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMitochondrial biogenesis
    Study

    ratn: not reported in source

    Red and white gastrocnemius muscle
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    1 mg/g body weight/day · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Rats were treated with AICAR (1 mg/g body weight/day) for 14 days, resulting in increased expression levels of nicotinamide phosphoribosyltransferase (NAMPT), peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), glucose transporter 4 proteins, and enhanced mitochondrial biogenesis.
    1 context sentence
    Summary · context
    These changes were more prominent in white rather than red gastrocnemius muscle or were only observed in the white gastrocnemius.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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