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Study · Animal study (in vivo) · rat · 2023

5 results

AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation.

Yang H, Wang Y, Zhen S, Wang B, Jiao M, Liu L, Li D, Zhu H, Xie M

Acta biochimica et biophysica Sinica1 Mar 2023Cited by 15 (Europe PMC)

PMID36971458 (opens in a new tab)PMCIDPMC10160234 (opens in a new tab)DOI10.3724/abbs.2023039 (opens in a new tab)PepBankPUB-36971458
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with cancer-induced bone pain, intrathecal AICAR reduced Drp1 GTPase activity.

    In plain wordsIn rats with cancer-induced bone pain, AICAR reduced Drp1 enzyme activity.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseDrp1 GTPase activity
    Study

    ratn: not reported in source

    male Sprague-Dawley rats with cancer-induced bone pain
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Intrathecal injection of the AMPK activator AICAR in the lumbar spinal cord reduces dynamin-related protein 1 (Drp1) GTPase activity and suppresses NLRP3 inflammasome activation.
    1 context sentence
    Summary · context
    In the current study, male Sprague-Dawley (SD) rats are used to establish a cancer-induced bone pain (CIBP) model by intratibial injection of MRMT-1 rat breast carcinoma cells.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with cancer-induced bone pain, intrathecal AICAR suppressed NLRP3 inflammasome activation.

    In plain wordsIn rats with cancer-induced bone pain, AICAR suppressed NLRP3 inflammasome activation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNLRP3 inflammasome activation
    Study

    ratn: not reported in source

    male Sprague-Dawley rats with cancer-induced bone pain
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Intrathecal injection of the AMPK activator AICAR in the lumbar spinal cord reduces dynamin-related protein 1 (Drp1) GTPase activity and suppresses NLRP3 inflammasome activation.
    1 context sentence
    Summary · context
    In the current study, male Sprague-Dawley (SD) rats are used to establish a cancer-induced bone pain (CIBP) model by intratibial injection of MRMT-1 rat breast carcinoma cells.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cancer-induced bone pain, intrathecal AICAR alleviated pain behaviors.

    In plain wordsIn rats with cancer-induced bone pain, AICAR reduced pain behaviors.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePain behaviors
    Study

    ratn: not reported in source

    male Sprague-Dawley rats with cancer-induced bone pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    This effect consequently alleviates pain behaviors in CIBP rats.
    2 context sentences
    Summary · context
    Intrathecal injection of the AMPK activator AICAR in the lumbar spinal cord reduces dynamin-related protein 1 (Drp1) GTPase activity and suppresses NLRP3 inflammasome activation.
    Summary · context
    In the current study, male Sprague-Dawley (SD) rats are used to establish a cancer-induced bone pain (CIBP) model by intratibial injection of MRMT-1 rat breast carcinoma cells.
  4. 04LabIn vitro (cells)Mechanism

    In C6 rat glioma cells, AICAR restored IL-1β-impaired mitochondrial membrane potential.

    In plain wordsIn cells from rats, AICAR restored mitochondrial membrane potential impaired by IL-1β.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    ratn: not reported in source

    IL-1β-treated C6 rat glioma cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell research on C6 rat glioma cells indicates that AICAR treatment restores IL-1β-induced impairment of mitochondrial membrane potential and elevation of mitochondrial reactive oxygen species (ROS).
  5. 05LabIn vitro (cells)Mechanism

    In C6 rat glioma cells, AICAR reversed the IL-1β-induced elevation in mitochondrial reactive oxygen species.

    In plain wordsIn cells from rats, AICAR reduced the rise in mitochondrial reactive oxygen species induced by IL-1β.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMitochondrial reactive oxygen species
    Study

    ratn: not reported in source

    IL-1β-treated C6 rat glioma cells
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cell research on C6 rat glioma cells indicates that AICAR treatment restores IL-1β-induced impairment of mitochondrial membrane potential and elevation of mitochondrial reactive oxygen species (ROS).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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