Study · Animal study (in vivo) · rat · 2026
20 resultsGan L, Li W, Zhang Y, Zeng J, Xu B
Cellular and molecular life sciences : CMLS5 Feb 2026Cited by 6 (Europe PMC)
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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.
20 results from studies that gave the peptide. No result from this study comes from people.
In a study of rats and HK-2 cells with renal injury, AICAR activated AMPK.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR activated AMPK.
ratn: not reported in source
IRI-AKISource sentences
we demonstrated that AICAR activates AMPK,
In a study of rats and HK-2 cells with renal injury, AICAR significantly downregulated TXNIP.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR reduced TXNIP.
ratn: not reported in source
IRI-AKISource sentences
we demonstrated that AICAR activates AMPK, leading to the significant downregulation of TXNIP and NLRP3,
In a study of rats and HK-2 cells with renal injury, AICAR significantly downregulated NLRP3.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR reduced NLRP3.
ratn: not reported in source
IRI-AKISource sentences
we demonstrated that AICAR activates AMPK, leading to the significant downregulation of TXNIP and NLRP3,
In a study of rats and HK-2 cells with renal injury, AICAR blocked Caspase-1-dependent IL-1β release.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR blocked release of the inflammatory signal IL-1β.
ratn: not reported in source
IRI-AKISource sentences
blocks Caspase-1-dependent release of IL-1β and IL-18,
In a study of rats and HK-2 cells with renal injury, AICAR blocked Caspase-1-dependent IL-18 release.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR blocked release of the inflammatory signal IL-18.
ratn: not reported in source
IRI-AKISource sentences
blocks Caspase-1-dependent release of IL-1β and IL-18,
In a study of rats and HK-2 cells with renal injury, AICAR suppressed pyroptosis.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR suppressed inflammatory cell death.
ratn: not reported in source
IRI-AKISource sentences
and ultimately suppresses pyroptosis, thereby alleviating renal inflammatory injury.
In a study of rats and HK-2 cells with renal injury, AICAR alleviated renal inflammatory injury.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR reduced inflammatory injury.
ratn: not reported in source
IRI-AKISource sentences
and ultimately suppresses pyroptosis, thereby alleviating renal inflammatory injury.
In rats with IRI-AKI, AICAR reduced reactive oxygen species production in renal tissues.
In plain wordsIn rats with kidney injury, AICAR reduced reactive oxygen species in kidney tissue.
ratn: not reported in source
IRI-AKISource sentences
Furthermore, AICAR restored mitochondrial membrane potential and ATP levels in H/R-treated HK-2 cells, reduced reactive oxygen species production in renal tissues of IRI-AKI rats, and elevated levels of antioxidant enzymes.
In rats with IRI-AKI, AICAR elevated antioxidant enzyme levels.
In plain wordsIn rats with kidney injury, AICAR increased antioxidant enzyme levels.
ratn: not reported in source
IRI-AKISource sentences
Furthermore, AICAR restored mitochondrial membrane potential and ATP levels in H/R-treated HK-2 cells, reduced reactive oxygen species production in renal tissues of IRI-AKI rats, and elevated levels of antioxidant enzymes.
In the IRI-AKI study, AICAR restored multiple metabolites associated with glycolysis, the TCA cycle, the urea cycle, and tryptophan metabolism.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR restored multiple metabolites associated with several metabolic pathways.
ratn: not reported in source
IRI-AKISource sentences
Concurrently, utilizing targeted metabolomics technology, we discovered that AICAR effectively restores the levels of multiple metabolites associated with glycolysis, the TCA cycle, the urea cycle, and tryptophan metabolism and alleviates lipid deposition in IRI-AKI.
In the IRI-AKI study, AICAR alleviated lipid deposition.
In plain wordsIn rats studied alongside cells with kidney injury, AICAR reduced fat deposition.
ratn: not reported in source
IRI-AKISource sentences
Concurrently, utilizing targeted metabolomics technology, we discovered that AICAR effectively restores the levels of multiple metabolites associated with glycolysis, the TCA cycle, the urea cycle, and tryptophan metabolism and alleviates lipid deposition in IRI-AKI.
In a study of HK-2 cells and rats with renal injury, AICAR activated AMPK.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR activated AMPK.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
we demonstrated that AICAR activates AMPK,
In a study of HK-2 cells and rats with renal injury, AICAR significantly downregulated TXNIP.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR reduced TXNIP.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
we demonstrated that AICAR activates AMPK, leading to the significant downregulation of TXNIP and NLRP3,
In a study of HK-2 cells and rats with renal injury, AICAR significantly downregulated NLRP3.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR reduced NLRP3.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
we demonstrated that AICAR activates AMPK, leading to the significant downregulation of TXNIP and NLRP3,
In a study of HK-2 cells and rats with renal injury, AICAR blocked Caspase-1-dependent IL-1β release.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR blocked release of the inflammatory signal IL-1β.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
blocks Caspase-1-dependent release of IL-1β and IL-18,
In a study of HK-2 cells and rats with renal injury, AICAR blocked Caspase-1-dependent IL-18 release.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR blocked release of the inflammatory signal IL-18.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
blocks Caspase-1-dependent release of IL-1β and IL-18,
In a study of HK-2 cells and rats with renal injury, AICAR suppressed pyroptosis.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR suppressed inflammatory cell death.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
and ultimately suppresses pyroptosis, thereby alleviating renal inflammatory injury.
In a study of HK-2 cells and rats with renal injury, AICAR alleviated renal inflammatory injury.
In plain wordsIn cells studied alongside rats with kidney injury, AICAR reduced inflammatory injury.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
and ultimately suppresses pyroptosis, thereby alleviating renal inflammatory injury.
In H/R-treated HK-2 cells, AICAR restored mitochondrial membrane potential.
In plain wordsIn cells with low-oxygen and reoxygenation injury, AICAR restored mitochondrial membrane potential.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
Furthermore, AICAR restored mitochondrial membrane potential and ATP levels in H/R-treated HK-2 cells, reduced reactive oxygen species production in renal tissues of IRI-AKI rats, and elevated levels of antioxidant enzymes.
In H/R-treated HK-2 cells, AICAR restored ATP levels.
In plain wordsIn cells with low-oxygen and reoxygenation injury, AICAR restored levels of the energy molecule ATP.
humann: not reported in source
H/R-treated HK-2 cellsSource sentences
Furthermore, AICAR restored mitochondrial membrane potential and ATP levels in H/R-treated HK-2 cells, reduced reactive oxygen species production in renal tissues of IRI-AKI rats, and elevated levels of antioxidant enzymes.
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.
Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC
Terms as the source lists them.
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