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Study · Animal study (in vivo) · rat · 2024

2 results

AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins.

Rajan KE, Nishanthini B, Sowndharya S

Neurochemical research18 Nov 2024Cited by 2 (Europe PMC)

PMID39556261 (opens in a new tab)DOI10.1007/s11064-024-04285-8 (opens in a new tab)PepBankPUB-39556261
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats exposed to chronic restraint stress, AICAR treatment improved memory.

    In plain wordsIn rats exposed to chronic restraint stress, AICAR improved memory.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseMemory
    Study

    ratn: not reported in source

    Early adolescent rats exposed to chronic restraint stress
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The AICAR treated CRS rats showed improved memory and altered metabolites and other molecules (HPRT, SERT, PSD-95 and BDNF) levels were restored.
    1 context sentence
    Summary · context
    To understand the underlying mechanism, brain metabolites and associated signaling molecules were examined in early adolescent rat experienced CRS.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats exposed to chronic restraint stress, analysis showed reduced endogenous AICAR.

    In plain wordsIn rats exposed to chronic restraint stress, natural AICAR levels were lower.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNatural AICAR level
    Study

    ratn: not reported in source

    Early adolescent rats exposed to chronic restraint stress
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Further analysis showed reduction of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR, a metabolite involved in purine metabolism) an AMP kinase activator,
    1 context sentence
    Summary · context
    To understand the underlying mechanism, brain metabolites and associated signaling molecules were examined in early adolescent rat experienced CRS.

    This result measures the body's own AICAR (acadesine). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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