AICAR (acadesine) studies: 330 papers with results
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- AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.
Cieslik KA · Journal of molecular and cellular cardiology · 2013
Animal study (in vivo) · mouse · 8 results
- 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.
Prasad R · Journal of neuroscience research · 2006
Animal study (in vivo) · rat · 7 results
- Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations.
Halseth AE · Biochemical and biophysical research communications · 2002
Animal study (in vivo) · mouse · 4 results
- Chronic AMPK stimulation attenuates adaptive signaling in dystrophic skeletal muscle.
Ljubicic V · American journal of physiology. Cell physiology · 2012
Animal study (in vivo) · mouse · 7 results
- Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway.
Ye G · Journal of pain research · 2021
Animal study (in vivo) · rat · 1 result
- Effect of exercise intensity on isoform-specific expressions of NT-PGC-1 α mRNA in mouse skeletal muscle.
Wen X · BioMed research international · 2014
Animal study (in vivo) · mouse · 3 results
- Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism.
Lesniewski LA · Mechanisms of ageing and development · 2012
Animal study (in vivo) · mouse · 3 results
- AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.
Holmes BF · American journal of physiology. Endocrinology and metabolism · 2004
Animal study (in vivo) · mouse · 3 results
- Exercise-mimetic AICAR transiently benefits brain function.
Guerrieri D · Oncotarget · 2015
Animal study (in vivo) · mouse · 8 results
- Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle.
Pruznak AM · The Journal of nutrition · 2008
Animal study (in vivo) · rat · 15 results
- Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease.
Ahmad W · Molecular neurobiology · 2017
Animal study (in vivo) · caenorhabditis elegans · 1 result
- AMPK activation attenuates inflammatory response to reduce ambient PM2.5-induced metabolic disorders in healthy and diabetic mice.
Pan K · Ecotoxicology and environmental safety · 2019
Animal study (in vivo) · mouse · 4 results
- 5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions.
Gaskin FS · American journal of physiology. Heart and circulatory physiology · 2007
Animal study (in vivo) · mouse · 8 results
- AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat.
Banek CT · American journal of physiology. Heart and circulatory physiology · 2013
Animal study (in vivo) · rat · 11 results
- AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.
Drake JC · American journal of physiology. Regulatory, integrative and comparative physiology · 2010
Animal study (in vivo) · mouse · 13 results
- Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis.
Suzuki J · Investigative ophthalmology & visual science · 2012
Animal study (in vivo) · mouse · 10 results
- Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles.
Ravel-Chapuis A · Human molecular genetics · 2018
Animal study (in vivo) · mouse · 4 results
- Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.
Liu W · Journal of affective disorders · 2014
Animal study (in vivo) · mouse · 2 results
- Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy.
Khan M · BMC neuroscience · 2015
Animal study (in vivo) · rat · 1 result
- Metformin preconditioning protects Daphnia pulex from lethal hypoxic insult involving AMPK, HIF and mTOR signaling.
Sheng B · Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2012
Animal study (in vivo) · daphnia pulex · 2 results
- AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle.
Thomson DM · The Journal of physiology · 2009
Animal study (in vivo) · rat · 1 result
- Potential role of lipin-1 in exercise-induced mitochondrial biogenesis.
Higashida K · Biochemical and biophysical research communications · 2008
Animal study (in vivo) · rat · 1 result
- Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle.
Sasaki T · American journal of physiology. Endocrinology and metabolism · 2014
Animal study (in vivo) · mouse · 11 results
- Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.
Cao XJ · Brain research · 2021
Animal study (in vivo) · rat · 3 results
- AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation.
Kong L · Frontiers in pharmacology · 2021
Animal study (in vivo) · rat · 7 results
- Chronic Treatment with the AMPK Agonist AICAR Prevents Skeletal Muscle Pathology but Fails to Improve Clinical Outcome in a Mouse Model of Severe Spinal Muscular Atrophy.
Cerveró C · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016
Animal study (in vivo) · mouse · 10 results
- AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.
Lane SL · The Journal of physiology · 2020
Animal study (in vivo) · mouse · 5 results
- AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model.
Hu L · Journal of molecular medicine (Berlin, Germany) · 2019
Animal study (in vivo) · rat · 13 results
- Sustained AMPK activation improves muscle function in a mitochondrial myopathy mouse model by promoting muscle fiber regeneration.
Peralta S · Human molecular genetics · 2016
Animal study (in vivo) · mouse · 5 results
- AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization.
Lu G · The journal of headache and pain · 2024
Animal study (in vivo) · mouse · 12 results
- Preconditioning mice with activators of AMPK ameliorates ischemic acute kidney injury in vivo.
Lieberthal W · American journal of physiology. Renal physiology · 2016
Animal study (in vivo) · mouse · 10 results
- In vivo activating transcription factor 3 silencing ameliorates the AMPK compensatory effects for ER stress-mediated β-cell dysfunction during the progression of type-2 diabetes.
Kim JY · Cellular signalling · 2013
Animal study (in vivo) · rat · 5 results
- Caudal fourth ventricular administration of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside regulates glucose and counterregulatory hormone profiles, dorsal vagal complex metabolosensory neuron function, and hypothalamic Fos expression.
Ibrahim BA · Journal of neuroscience research · 2013
Animal study (in vivo) · rat · 8 results
- AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase.
Gaskin FS · Microcirculation (New York, N.Y. : 1994) · 2009
Animal study (in vivo) · mouse · 3 results
- Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma.
Kim TB · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2007
Animal study (in vivo) · mouse · 16 results
- Aicar treatment reduces interstitial fibrosis in aging mice: Suppression of the inflammatory fibroblast.
Cieslik KA · Journal of molecular and cellular cardiology · 2017
Animal study (in vivo) · mouse · 6 results
- AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin.
Börgeson E · Diabetologia · 2017
Animal study (in vivo) · mouse · 11 results
- Combined pharmacological activation of AMPK and PPARδ potentiates the effects of exercise in trained mice.
Manio MC · Physiological reports · 2016
Animal study (in vivo) · mouse · 18 results
- Short-term adenosine monophosphate-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside treatment increases the sirtuin 1 protein expression in skeletal muscle.
Suwa M · Metabolism: clinical and experimental · 2011
Animal study (in vivo) · rat · 10 results
- κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation.
Zhang S · European journal of pharmacology · 2018
Animal study (in vivo) · rat · 9 results
- Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
Singh I · Immunology · 2018
Animal study (in vivo) · mouse · 8 results
- AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis.
Zhang X · Scientific reports · 2016
Animal study (in vivo) · mouse · 14 results
- Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats.
Watanabe K · International journal of molecular sciences · 2021
Animal study (in vivo) · rat · 1 result
- AMPK activation ameliorates D-GalN/LPS-induced acute liver failure by upregulating Foxo3A to induce autophagy.
Liu YM · Experimental cell research · 2017
Animal study (in vivo) · mouse · 10 results
- Aerobic exercise increases tear secretion in type 2 diabetic mice.
Sano K · Investigative ophthalmology & visual science · 2014
Animal study (in vivo) · mouse · 3 results
- Activation of AMPK ameliorates acute severe pancreatitis by suppressing pancreatic acinar cell necroptosis in obese mice models.
Wang K · Cell death discovery · 2023
Animal study (in vivo) · mouse · 10 results
- AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway.
Chen Y · European journal of pharmacology · 2017
Animal study (in vivo) · mouse · 5 results
- AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion.
Idrovo JP · Molecular medicine (Cambridge, Mass.) · 2015
Animal study (in vivo) · rat · 13 results
- Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats.
Pavlov TS · Frontiers in physiology · 2017
Animal study (in vivo) · rat · 3 results
- Stimulation of Brain AMP-Activated Protein Kinase Attenuates Inflammation and Acute Lung Injury in Sepsis.
Mulchandani N · Molecular medicine (Cambridge, Mass.) · 2015
Animal study (in vivo) · mouse · 13 results