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Study · Animal study (in vivo) · rat · 2018

3 results

Hypothalamic AMPK-induced autophagy ameliorates hypercatabolism in septic rats by regulating POMC expression.

Cao C, Gao T, Cheng Y, Cheng M, Su T, Xi F, Wu C, Yu W

Biochemical and biophysical research communications26 Feb 2018Cited by 17 (Europe PMC)

PMID29496447 (opens in a new tab)DOI10.1016/j.bbrc.2018.02.184 (opens in a new tab)PepBankPUB-29496447
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In septic rats, central AICAR reduced hypercatabolism compared with saline.

    In plain wordsIn rats with sepsis, AICAR injection into the third ventricle reduced hypercatabolism compared with saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypercatabolism
    Study

    ratn: not reported in source

    LPS-induced sepsis
    Comparator
    Saline
    Outcome group
    Muscle injury and repair · Metabolic and weight
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Central activation of AMPK-induced autophagy pathway via third ventricle injection of AICAR, an AMPK activator, could efficiently ameliorate hypercatabolism as well as attenuate the elevated POMC expression rather than other neuropeptides.
    1 context sentence
    Summary · context
    Then, rats were injected with AICAR or saline into third ventricle and promptly intraperitoneally injected with LPS or saline.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In septic rats, central AICAR attenuated elevated hypothalamic POMC expression compared with saline.

    In plain wordsIn rats with sepsis, central AICAR reduced elevated POMC expression in the hypothalamus compared with saline.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHypothalamic POMC expression
    Study

    ratn: not reported in source

    LPS-induced sepsis
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Central activation of AMPK-induced autophagy pathway via third ventricle injection of AICAR, an AMPK activator, could efficiently ameliorate hypercatabolism as well as attenuate the elevated POMC expression rather than other neuropeptides.
    1 context sentence
    Summary · context
    Then, rats were injected with AICAR or saline into third ventricle and promptly intraperitoneally injected with LPS or saline.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In septic rats, central AICAR did not attenuate expression of the other assessed neuropeptides compared with saline.

    In plain wordsIn rats with sepsis, central AICAR did not reduce expression of the other assessed neuropeptides compared with saline.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeOther neuropeptide expression
    Study

    ratn: not reported in source

    LPS-induced sepsis
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · third ventricle injectionAs given in this study (rat).

    Source sentences

    Summary
    Moreover, Central activation of AMPK-induced autophagy pathway via third ventricle injection of AICAR, an AMPK activator, could efficiently ameliorate hypercatabolism as well as attenuate the elevated POMC expression rather than other neuropeptides.
    1 context sentence
    Summary · context
    Then, rats were injected with AICAR or saline into third ventricle and promptly intraperitoneally injected with LPS or saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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