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Study · Animal study (in vivo) · rat · 2024

11 results

Central administration of AICAR attenuates hypertension via AMPK/Nrf2 pathway in the hypothalamic paraventricular nucleus of hypertensive rats.

Fu LY, Yang Y, Tian H, Jia XY, Liu KL, Gao HL, Li Y, Qi J, Yu XJ, Kang YM

European journal of pharmacology9 Feb 2024Cited by 8 (Europe PMC)

PMID38341079 (opens in a new tab)DOI10.1016/j.ejphar.2024.176373 (opens in a new tab)PepBankPUB-38341079
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated reduced PVN p-AMPK expression.

    In plain wordsIn rats with hypertension, AICAR restored reduced brain p-AMPK expression.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep-AMPK expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    Compared to the SHAM group, the PVN of 2K1C hypertensive rats decreased p-AMPK and p-Nrf2 expression
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated reduced PVN p-Nrf2 expression.

    In plain wordsIn rats with hypertension, AICAR restored reduced brain p-Nrf2 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep-Nrf2 expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    Compared to the SHAM group, the PVN of 2K1C hypertensive rats decreased p-AMPK and p-Nrf2 expression
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated increased PVN Fra-Like expression.

    In plain wordsIn rats with hypertension, AICAR reduced elevated brain Fra-Like expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseFra-Like expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    increased Fra-Like, NAD(P)H oxidase (NOX)2, NOX4, tumor necrosis factor-α and interleukin (IL)-1β expression, elevated ROS levels
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated increased PVN NOX2 expression.

    In plain wordsIn rats with hypertension, AICAR reduced elevated brain NOX2 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNOX2 expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    increased Fra-Like, NAD(P)H oxidase (NOX)2, NOX4, tumor necrosis factor-α and interleukin (IL)-1β expression, elevated ROS levels
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated increased PVN NOX4 expression.

    In plain wordsIn rats with hypertension, AICAR reduced elevated brain NOX4 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNOX4 expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    increased Fra-Like, NAD(P)H oxidase (NOX)2, NOX4, tumor necrosis factor-α and interleukin (IL)-1β expression, elevated ROS levels
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated increased PVN tumor necrosis factor-α expression.

    In plain wordsIn rats with hypertension, AICAR reduced elevated brain tumor necrosis factor-α expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTNF-alpha expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    increased Fra-Like, NAD(P)H oxidase (NOX)2, NOX4, tumor necrosis factor-α and interleukin (IL)-1β expression, elevated ROS levels
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated increased PVN IL-1β expression.

    In plain wordsIn rats with hypertension, AICAR reduced elevated brain IL-1β expression.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-1beta expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    increased Fra-Like, NAD(P)H oxidase (NOX)2, NOX4, tumor necrosis factor-α and interleukin (IL)-1β expression, elevated ROS levels
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated elevated PVN ROS levels.

    In plain wordsIn rats with hypertension, AICAR reduced elevated brain reactive oxygen species levels.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseReactive oxygen species
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    increased Fra-Like, NAD(P)H oxidase (NOX)2, NOX4, tumor necrosis factor-α and interleukin (IL)-1β expression, elevated ROS levels
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated decreased PVN superoxide dismutase 1 expression.

    In plain wordsIn rats with hypertension, AICAR restored reduced brain superoxide dismutase 1 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSuperoxide dismutase 1 expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    decreased superoxide dismutase 1 and IL-10 expression, and elevated plasma norepinephrine levels.
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated decreased PVN IL-10 expression.

    In plain wordsIn rats with hypertension, AICAR restored reduced brain IL-10 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseIL-10 expression
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    decreased superoxide dismutase 1 and IL-10 expression, and elevated plasma norepinephrine levels.
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In hypertensive rats, AICAR ameliorated elevated plasma norepinephrine levels.

    In plain wordsIn rats with hypertension, AICAR reduced elevated blood norepinephrine levels.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreasePlasma norepinephrine
    Study

    ratn: not reported in source

    Adult male Sprague-Dawley rats with two-kidney, one-clip hypertension
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · Bilateral hypothalamic paraventricular nucleus microinjection · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Bilateral PVN microinjection of AICAR significantly ameliorated these changes.
    3 context sentences
    Summary · context
    decreased superoxide dismutase 1 and IL-10 expression, and elevated plasma norepinephrine levels.
    Summary · context
    Adult male Sprague-Dawley rats were utilized to induce two-kidney, one-clip (2K1C) hypertension via constriction of the right renal artery.
    Summary · context
    Bilateral PVN was microinjected with either artificial cerebrospinal fluid or AICAR once a day for 4 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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