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Study · Animal study (in vivo) · mouse · 2024

14 results

Akebia saponin D attenuates allergic airway inflammation through AMPK activation.

Xuan L, Yang S, Ren L, Liu H, Zhang W, Sun Y, Xu B, Gong L, Liu L

Journal of natural medicines4 Jan 2024Cited by 7 (Europe PMC)

PMID38175326 (opens in a new tab)DOI10.1007/s11418-023-01762-2 (opens in a new tab)PepBankPUB-38175326
Publisher pagePubMedAsk about this study
Jump to 14 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated eosinophil infiltration.

    In plain wordsIn mice with induced asthma, AICAR reduced eosinophil infiltration.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseEosinophil infiltration
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Immune response · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated neutrophil infiltration.

    In plain wordsIn mice with induced asthma, AICAR reduced neutrophil infiltration.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNeutrophil infiltration
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Immune response · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated monocyte infiltration.

    In plain wordsIn mice with induced asthma, AICAR reduced monocyte infiltration.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMonocyte infiltration
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Immune response · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated lymphocyte infiltration.

    In plain wordsIn mice with induced asthma, AICAR reduced lymphocyte infiltration.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLymphocyte infiltration
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Immune response · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated TNF-α production.

    In plain wordsIn mice with induced asthma, AICAR reduced TNF-α production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTNF-α production
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated IL-6 production.

    In plain wordsIn mice with induced asthma, AICAR reduced IL-6 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-6 production
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated IL-4 production.

    In plain wordsIn mice with induced asthma, AICAR reduced IL-4 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-4 production
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR attenuated IL-13 production.

    In plain wordsIn mice with induced asthma, AICAR reduced IL-13 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-13 production
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Infiltration of eosinophils, neutrophils, monocytes, and lymphocytes, and production of TNF-α, IL-6, IL-4, and IL-13 were attenuated in ASD and AICAR treated mice.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR ameliorated lung histopathological changes.

    In plain wordsIn mice with induced asthma, AICAR reduced lung tissue abnormalities.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung histopathology
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Lung histopathological changes were also ameliorated after ASD and AICAR treatment.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with induced asthma, AICAR increased lung p-AMPK expression.

    In plain wordsIn mice with induced asthma, AICAR increased p-AMPK expression in lung tissue.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLung p-AMPK expression
    Study

    mousen: not reported in source

    OVA-induced asthma
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    100 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    Additionally, it showed that treatment with ASD and AICAR increased p-AMPK expression in the lung tissues.
    1 context sentence
    Summary · context
    Asthma murine model was induced by ovalbumin (OVA) challenge and treated with ASD (150 and 300 mg/kg) or AICAR (100 mg/kg).
  11. 11LabIn vitro (cells)Mechanism

    In stimulated BEAS-2B cells, AICAR pretreatment significantly inhibited TNF-α production.

    In plain wordsIn cells, AICAR pretreatment reduced TNF-α production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTNF-α production
    Study

    humann: not reported in source

    BEAS-2B cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    1 mMAs given in this study (human).

    Source sentences

    Summary
    Pretreatment with ASD and AICAR significantly inhibited TNF-α and IL-6 production from BEAS-2B cells, and IL-13 production from BMMCs.
    1 context sentence
    Summary · context
    Human lung epithelial BEAS-2B cells and bone marrow-derived mast cells (BMMCs) were pretreated with ASD (50, 100 and 200 μΜ) and AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) (1 mM), and then stimulated with lipopolysaccharide (LPS) or IL-33.
  12. 12LabIn vitro (cells)Mechanism

    In stimulated BEAS-2B cells, AICAR pretreatment significantly inhibited IL-6 production.

    In plain wordsIn cells, AICAR pretreatment reduced IL-6 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-6 production
    Study

    humann: not reported in source

    BEAS-2B cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    1 mMAs given in this study (human).

    Source sentences

    Summary
    Pretreatment with ASD and AICAR significantly inhibited TNF-α and IL-6 production from BEAS-2B cells, and IL-13 production from BMMCs.
    1 context sentence
    Summary · context
    Human lung epithelial BEAS-2B cells and bone marrow-derived mast cells (BMMCs) were pretreated with ASD (50, 100 and 200 μΜ) and AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) (1 mM), and then stimulated with lipopolysaccharide (LPS) or IL-33.
  13. 13LabIn vitro (cells)Mechanism

    In stimulated bone marrow-derived mast cells, AICAR pretreatment significantly inhibited IL-13 production.

    In plain wordsIn cells, AICAR pretreatment reduced IL-13 production.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseIL-13 production
    Study

    n: not reported in source

    bone marrow-derived mast cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    1 mMAs given in this study.

    Source sentences

    Summary
    Pretreatment with ASD and AICAR significantly inhibited TNF-α and IL-6 production from BEAS-2B cells, and IL-13 production from BMMCs.
    1 context sentence
    Summary · context
    Human lung epithelial BEAS-2B cells and bone marrow-derived mast cells (BMMCs) were pretreated with ASD (50, 100 and 200 μΜ) and AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) (1 mM), and then stimulated with lipopolysaccharide (LPS) or IL-33.
  14. 14LabIn vitro (cells)Mechanism

    In BEAS-2B cells, AICAR pretreatment significantly increased p-AMPK expression.

    In plain wordsIn cells, AICAR pretreatment increased p-AMPK expression.

    Peptide
    AICAR (acadesine)
    Outcome
    Increasep-AMPK expression
    Study

    humann: not reported in source

    BEAS-2B cells
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    1 mMAs given in this study (human).

    Source sentences

    Summary
    Moreover, pretreatment with ASD and AICAR significantly increased p-AMPK expression in BEAS-2B cells.
    1 context sentence
    Summary · context
    Human lung epithelial BEAS-2B cells and bone marrow-derived mast cells (BMMCs) were pretreated with ASD (50, 100 and 200 μΜ) and AMPK activator 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) (1 mM), and then stimulated with lipopolysaccharide (LPS) or IL-33.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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