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Study · Animal study (in vivo) · mouse · 2020

2 results

AMPK activation ameliorates fine particulate matter-induced hepatic injury.

Song L, Jiang S, Pan K, Du X, Zeng X, Zhang J, Zhou J, Sun Q, Xie Y, Zhao J

Environmental science and pollution research international8 Apr 2020Cited by 13 (Europe PMC)

PMID32270451 (opens in a new tab)DOI10.1007/s11356-020-08624-4 (opens in a new tab)PepBankPUB-32270451
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, AICAR increased hepatic GLUT4 expression compared with PM mice.

    In plain wordsIn mice exposed to particles, AICAR increased liver GLUT4 expression compared with PM mice.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHepatic GLUT4 expression
    Study

    mousen: not reported in source

    PM2.5 exposure
    Comparator
    PM mice
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The AICAR injection upregulated the expressions of GLUT4 in the liver of PM-AIC mice when compared with the PM mice.
    2 context sentences
    Summary · context
    Thirty-two 6-week-old male C57BL/6 mice were exposed to filtered air (FA) or concentrated PM2.5 for 12 weeks using Shanghai Meteorological and Environmental Animal Exposure System ("Shanghai-METAS"), respectively.
    Summary · context
    At week 11, the mice began to be treated with intraperitoneal injection of normal 0.9% saline or AMPK activator (AICAR).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In PM-exposed mice, AICAR did not significantly affect histopathological condition.

    In plain wordsIn mice exposed to particles, AICAR did not significantly change tissue pathology compared with PM mice.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeHistopathological condition
    Study

    mousen: not reported in source

    PM2.5 exposure
    Comparator
    PM mice
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    However, there were no significant effects of AICAR on histopathological condition.
    2 context sentences
    Summary · context
    Thirty-two 6-week-old male C57BL/6 mice were exposed to filtered air (FA) or concentrated PM2.5 for 12 weeks using Shanghai Meteorological and Environmental Animal Exposure System ("Shanghai-METAS"), respectively.
    Summary · context
    At week 11, the mice began to be treated with intraperitoneal injection of normal 0.9% saline or AMPK activator (AICAR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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