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Study · Animal study (in vivo) · rat · 2017

8 results

5-Aminoimidazole-4-carboxamide ribonucleotide prevents fat gain following the cessation of voluntary physical activity.

Ruegsegger GN, Sevage JA, Childs TE, Grigsby KB, Booth FW

Experimental physiology19 Sept 2017Cited by 3 (Europe PMC)

PMID28786140 (opens in a new tab)DOI10.1113/ep086335 (opens in a new tab)PepBankPUB-28786140
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats after wheel locking, AICAR prevented body fat gain compared with sedentary rats.

    In plain wordsIn rats, AICAR prevented fat gain after wheel locking compared with sedentary rats.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBody fat gain
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    sedentary rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    RUN and WL + AICAR prevented gains in body fat compared with SED and WL (P < 0.001).
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats after wheel locking, AICAR prevented body fat gain compared with wheel locking alone.

    In plain wordsIn rats, AICAR prevented fat gain compared with wheel locking alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBody fat gain
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    wheel-locked rats without AICAR
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    RUN and WL + AICAR prevented gains in body fat compared with SED and WL (P < 0.001).
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats after activity cessation, AICAR limited fat gain to levels comparable to continuously active rats.

    In plain wordsIn rats, AICAR limited fat gain to levels comparable to rats that remained active.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedBody fat gain versus continued activity
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    continuously active rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    AICAR prevented fat gains following the transition from physical activity to inactivity to levels comparable to rats that remained physically active.
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats after wheel locking, AICAR decreased omental cyclin A1 mRNA compared with sedentary rats.

    In plain wordsIn rats, AICAR reduced omental cyclin A1 mRNA compared with sedentary rats.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOmental cyclin A1 mRNA
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    sedentary rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    Cyclin A1 mRNA, a marker of cell proliferation, was decreased in omental, but not subcutaneous adipose tissue, in RUN and WL + AICAR compared with SED and WL groups (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats after wheel locking, AICAR decreased omental cyclin A1 mRNA compared with wheel locking alone.

    In plain wordsIn rats, AICAR reduced omental cyclin A1 mRNA compared with wheel locking alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOmental cyclin A1 mRNA
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    wheel-locked rats without AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    Cyclin A1 mRNA, a marker of cell proliferation, was decreased in omental, but not subcutaneous adipose tissue, in RUN and WL + AICAR compared with SED and WL groups (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats after wheel locking, AICAR did not decrease subcutaneous cyclin A1 mRNA compared with sedentary rats.

    In plain wordsIn rats, AICAR did not reduce subcutaneous cyclin A1 mRNA compared with sedentary rats.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSubcutaneous cyclin A1 mRNA
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    sedentary rats
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    Cyclin A1 mRNA, a marker of cell proliferation, was decreased in omental, but not subcutaneous adipose tissue, in RUN and WL + AICAR compared with SED and WL groups (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats after wheel locking, AICAR did not decrease subcutaneous cyclin A1 mRNA compared with wheel locking alone.

    In plain wordsIn rats, AICAR did not reduce subcutaneous cyclin A1 mRNA compared with wheel locking alone.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSubcutaneous cyclin A1 mRNA
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Comparator
    wheel-locked rats without AICAR
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    Cyclin A1 mRNA, a marker of cell proliferation, was decreased in omental, but not subcutaneous adipose tissue, in RUN and WL + AICAR compared with SED and WL groups (P < 0.05).
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR produced depot-specific cyclin A1 protein changes associated with prevention of fat gain.

    In plain wordsIn rats, AICAR changed cyclin A1 protein differently across fat depots in association with less fat gain.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedDepot-specific cyclin A1 protein changes
    Study

    ratn: not reported in source

    male Wistar rats after running-wheel locking
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 1 weekAs given in this study (rat).

    Source sentences

    Summary
    AICAR and continuous physical activity produced depot-specific changes in cyclin A1 mRNA and protein that were associated with the prevention of fat gain.
    1 context sentence
    Summary · context
    Male Wistar rats were either sedentary (SED) or given wheel access for 4 weeks, at which time rats with wheels continued running (RUN), had their wheel locked (WL) or had WL with daily AICAR injection (WL + AICAR) for 1 week.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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