Skip to content

Study · Animal study (in vivo) · mouse · 2021

4 results

AMPK upregulates KCa2.3 channels and ameliorates endothelial dysfunction in diet-induced obese mice.

Pang ZD, Wang Y, Song Z, She G, Ma XZ, Sun X, Wu W, Lai BC, Zhang J, Zhang Y, Du XJ, Shyy JYJ, Deng XL

Biochemical pharmacology11 Nov 2020Cited by 8 (Europe PMC)

PMID33186592 (opens in a new tab)DOI10.1016/j.bcp.2020.114337 (opens in a new tab)PepBankPUB-33186592
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In high-fat diet fed mice, AICAR restored endothelial KCa2.3 expression in mesenteric resistance arteries.

    In plain wordsIn mice fed a high-fat diet, AICAR restored potassium channel expression in artery lining cells.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEndothelial KCa2.3 expression
    Study

    mousen: not reported in source

    high-fat diet fed mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, in high-fat diet fed mice, 2-week treatment with AICAR restored endothelial KCa2.3 expression in mesenteric resistance arteries with improved endothelial dysfunction.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In high-fat diet fed mice, AICAR improved endothelial dysfunction.

    In plain wordsIn mice fed a high-fat diet, AICAR improved blood vessel lining dysfunction.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseEndothelial dysfunction
    Study

    mousen: not reported in source

    high-fat diet fed mice
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, in high-fat diet fed mice, 2-week treatment with AICAR restored endothelial KCa2.3 expression in mesenteric resistance arteries with improved endothelial dysfunction.
  3. 03LabIn vitro (cells)Mechanism

    In HUVECs, AMPK activation with AICAR significantly increased KCa2.3 expression.

    In plain wordsIn cells, AMPK activation with AICAR increased potassium channel expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseKCa2.3 expression after AMPK activation
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HUVECs, AMPK activation either by activators (AICAR, A769662 and MK-8722) or expression of the constitutively active form of AMPK significantly upregulated KCa2.3 expression.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 04LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In HUVECs, inhibitors or siRNAs targeting AMPK, ERK5, MEF2 or KLF2/4 abolished channel upregulation after pooled AMPK activation approaches including AICAR.

    In plain wordsIn cells, pathway inhibitors or gene silencing blocked channel increases from AMPK activation approaches that included AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBlockade of KCa2.3 upregulation
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Such effects were abolished by AMPK inhibitor (compound C) or AMPK α1-/α2-siRNA, extracellular-signal-regulated-kinase 5 (ERK5) inhibitor (ERK5-IN-1), and specific siRNA to myocyte-enhancer factor 2 (MEF2) or krüppel-like factor 2/4 (KLF2/4).
    1 context sentence
    Summary · context
    In HUVECs, AMPK activation either by activators (AICAR, A769662 and MK-8722) or expression of the constitutively active form of AMPK significantly upregulated KCa2.3 expression.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.