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Study · Animal study (in vivo) · rat · 2001

6 results

AMP-activated protein kinase activation prevents denervation-induced decline in gastrocnemius GLUT-4.

Paulsen SR, Rubink DS, Winder WW

Journal of applied physiology (Bethesda, Md. : 1985)1 Nov 2001Cited by 10 (Europe PMC)

PMID11641350 (opens in a new tab)DOI10.1152/jappl.2001.91.5.2102 (opens in a new tab)PepBankPUB-11641350
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, acute AICAR increased AMPK activity in denervated gastrocnemius.

    In plain wordsIn rats, AICAR increased AMPK activity in denervated gastrocnemius muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGastrocnemius AMPK activity
    Study

    ratn: not reported in source

    denervated skeletal muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Acute injections of AICAR resulted in significantly increased AMPK activity in denervated gastrocnemius but not soleus muscles.
    2 context sentences
    Summary · context
    Muscle AMPK can be chemically activated in rats using subcutaneous injections with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Summary · context
    In this study, the tibial nerve was sectioned on one side; the other was sham operated but without nerve section.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, acute AICAR did not increase AMPK activity in denervated soleus.

    In plain wordsIn rats, AICAR did not increase AMPK activity in denervated soleus muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSoleus AMPK activity
    Study

    ratn: not reported in source

    denervated skeletal muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Acute injections of AICAR resulted in significantly increased AMPK activity in denervated gastrocnemius but not soleus muscles.
    2 context sentences
    Summary · context
    Muscle AMPK can be chemically activated in rats using subcutaneous injections with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Summary · context
    In this study, the tibial nerve was sectioned on one side; the other was sham operated but without nerve section.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, acetyl-CoA carboxylase activity declined in gastrocnemius and soleus, in denervated and contralateral muscles, after acute AICAR.

    In plain wordsIn rats, enzyme activity declined in denervated and contralateral muscles after AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAcetyl-CoA carboxylase activity
    Study

    ratn: not reported in source

    denervated skeletal muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Acetyl-CoA carboxylase activity, a reporter of AMPK activation, declined in both gastrocnemius and soleus in both denervated and contralateral muscles.
    3 context sentences
    Summary · context
    Acute injections of AICAR resulted in significantly increased AMPK activity in denervated gastrocnemius but not soleus muscles.
    Summary · context
    Muscle AMPK can be chemically activated in rats using subcutaneous injections with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Summary · context
    In this study, the tibial nerve was sectioned on one side; the other was sham operated but without nerve section.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR prevented the denervation-induced decline in gastrocnemius GLUT4.

    In plain wordsIn rats, AICAR prevented GLUT4 loss in denervated gastrocnemius muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGastrocnemius GLUT4 preservation
    Study

    ratn: not reported in source

    denervated skeletal muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    1 mg/g body wt · subcutaneous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    When rats were injected with AICAR (1 mg/g body wt) for 3 days, the decline in GLUT-4 levels was prevented in denervated gastrocnemius muscles but not in denervated soleus muscles.
    2 context sentences
    Summary · context
    Muscle AMPK can be chemically activated in rats using subcutaneous injections with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Summary · context
    In this study, the tibial nerve was sectioned on one side; the other was sham operated but without nerve section.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, AICAR did not prevent the denervation-induced decline in soleus GLUT4.

    In plain wordsIn rats, AICAR did not prevent GLUT4 loss in denervated soleus muscle.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSoleus GLUT4 preservation
    Study

    ratn: not reported in source

    denervated skeletal muscles
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    1 mg/g body wt · subcutaneous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    When rats were injected with AICAR (1 mg/g body wt) for 3 days, the decline in GLUT-4 levels was prevented in denervated gastrocnemius muscles but not in denervated soleus muscles.
    2 context sentences
    Summary · context
    Muscle AMPK can be chemically activated in rats using subcutaneous injections with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Summary · context
    In this study, the tibial nerve was sectioned on one side; the other was sham operated but without nerve section.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, denervation-induced muscle atrophy was similar with AICAR and saline.

    In plain wordsIn rats, muscle wasting after denervation was similar with AICAR and saline.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeDenervation-induced muscle atrophy
    Study

    ratn: not reported in source

    denervated skeletal muscles
    Comparator
    Saline
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The extent of denervation-induced muscle atrophy was similar in AICAR-treated vs. saline-treated rats.
    2 context sentences
    Summary · context
    Muscle AMPK can be chemically activated in rats using subcutaneous injections with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).
    Summary · context
    In this study, the tibial nerve was sectioned on one side; the other was sham operated but without nerve section.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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