Exercise Improves Outcomes of Surgery on Fatty Liver in Mice: A Novel Effect Mediated by the AMPK Pathway.

Linecker M, Frick L, Kron P, Limani P, Kambakamba P, Tschuor C, Langiewicz M, Kachaylo E, Tian Y, Schneider MA, Ungethüm U, Calo N and 5 more

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Foti M, Dufour JF, Graf R, Humar B, Clavien PA

Annals of surgery1 Feb 2020Cited by 13 (Europe PMC)

PMID30138163DOI10.1097/sla.0000000000002904PepBankPUB-30138163

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with fatty liver, AICAR replicated the reversal of steatosis observed with exercise.
In plain wordsIn mice with fatty liver, AICAR replicated exercise-associated reversal of liver fat accumulation.
Peptide
AICAR (acadesine)
Outcome
DecreaseSteatosis
Study
mousen: not reported in source
diet-induced fatty liver
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Replacing exercise with AICAR was sufficient to replicate the above benefits.
2 context sentences(design, population, supporting numbers)
Summary · context
A 4-week-exercising program reversed steatosis, lowered insulin levels, and improved glucose tolerance.
Summary · context
We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Report a problemFND-3013816301
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with fatty liver, AICAR replicated the lowering of insulin levels observed with exercise.
In plain wordsIn mice with fatty liver, AICAR replicated exercise-associated lowering of insulin levels.
Peptide
AICAR (acadesine)
Outcome
DecreaseInsulin levels
Study
mousen: not reported in source
diet-induced fatty liver
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Replacing exercise with AICAR was sufficient to replicate the above benefits.
2 context sentences(design, population, supporting numbers)
Summary · context
A 4-week-exercising program reversed steatosis, lowered insulin levels, and improved glucose tolerance.
Summary · context
We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Report a problemFND-3013816302
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with fatty liver, AICAR replicated the improvement in glucose tolerance observed with exercise.
In plain wordsIn mice with fatty liver, AICAR replicated exercise-associated improvement in glucose tolerance.
Peptide
AICAR (acadesine)
Outcome
IncreaseGlucose tolerance
Study
mousen: not reported in source
diet-induced fatty liver
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Replacing exercise with AICAR was sufficient to replicate the above benefits.
2 context sentences(design, population, supporting numbers)
Summary · context
A 4-week-exercising program reversed steatosis, lowered insulin levels, and improved glucose tolerance.
Summary · context
We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Report a problemFND-3013816303
04AnimalAnimal study (in vivo)Efficacy outcome
In mice with fatty liver, AICAR replicated the enhanced ischemic tolerance observed with exercise.
In plain wordsIn mice with fatty liver, AICAR replicated exercise-associated improvement in liver tolerance to reduced blood flow.
Peptide
AICAR (acadesine)
Outcome
IncreaseHepatic ischemic tolerance
Study
mousen: not reported in source
diet-induced fatty liver
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Replacing exercise with AICAR was sufficient to replicate the above benefits.
2 context sentences(design, population, supporting numbers)
Summary · context
Exercise markedly enhanced the ischemic tolerance and the regenerative capacity of fatty liver.
Summary · context
We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Report a problemFND-3013816304
05AnimalAnimal study (in vivo)Efficacy outcome
In mice with fatty liver, AICAR replicated the enhanced regenerative capacity observed with exercise.
In plain wordsIn mice with fatty liver, AICAR replicated exercise-associated improvement in liver regeneration.
Peptide
AICAR (acadesine)
Outcome
IncreaseLiver regeneration
Study
mousen: not reported in source
diet-induced fatty liver
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Replacing exercise with AICAR was sufficient to replicate the above benefits.
2 context sentences(design, population, supporting numbers)
Summary · context
Exercise markedly enhanced the ischemic tolerance and the regenerative capacity of fatty liver.
Summary · context
We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Report a problemFND-3013816305
06AnimalAnimal study (in vivo)Efficacy outcome
In Western-diet-challenged mice, AICAR improved survival after extended hepatectomy.
In plain wordsIn mice given a Western diet, AICAR improved survival after extensive liver surgery.
Peptide
AICAR (acadesine)
Outcome
IncreaseSurvival after extended hepatectomy
Study
mousen: not reported in source
diet-induced fatty liver
Outcome group
Mortality · Liver
Studied dose
Dose not stated
Source sentences
Summary
Both exercise and AICAR improved survival after extended hepatectomy in mice challenged with a Western diet, indicating protection from resection-induced liver failure.
1 context sentence(design, population, supporting numbers)
Summary · context
We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Report a problemFND-3013816306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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