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Study · Animal study (in vivo) · rat · 2007

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Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.

Baggott JE, Morgan SL

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences1 Mar 2007Cited by 4 (Europe PMC)

PMID17408934 (opens in a new tab)PMCIDPMC1976409 (opens in a new tab)DOI10.1016/j.ejps.2007.02.006 (opens in a new tab)PepBankPUB-17408934
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with adjuvant arthritis, AICA riboside potentiated methotrexate efficacy.

    In plain wordsIn rats with arthritis, AICA riboside improved treatment efficacy compared with methotrexate alone.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseArthritis treatment efficacy
    Study

    ratn: not reported in source

    Adjuvant arthritis
    Comparator
    Methotrexate alone
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    EHNA was not efficacious, even at toxic levels, while AICA riboside potentiated the efficacy of MTX.
    2 context sentences
    Summary · context
    The objectives were: (1) to test the association of methotrexate (MTX) efficacy in rat adjuvant arthritis (rat AA) with interference of purine biosynthesis and adenosine metabolism and (2) to test the efficacy of erythro-9-(2-hydroxynon-3-yl) adenine (EHNA), an inhibitor of adenosine deaminase, and…
    Summary · context
    Radiographic and histologic examinations of the hind limbs were measures of efficacy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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