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Study · Animal study (in vivo) · sheep · 2011

1 result

Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep.

Laker RC, Henry BA, Wadley GD, Clarke IJ, Canny BJ, McConell GK

American journal of physiology. Regulatory, integrative and comparative physiology9 Dec 2010Cited by 10 (Europe PMC)

PMID21148475 (opens in a new tab)DOI10.1152/ajpregu.00079.2010 (opens in a new tab)PepBankPUB-21148475
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In sheep, direct femoral artery infusion of AICAR increased skeletal muscle AMPK phosphorylation.

    In plain wordsIn sheep, AICAR infusion into the femoral artery increased muscle AMPK phosphorylation.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSkeletal muscle AMPK phosphorylation
    Study

    sheepn: not reported in source

    Skeletal muscle of ovariectomized Corriedale ewes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · femoral artery infusionAs given in this study (sheep).

    Source sentences

    Summary
    Direct infusion of the AMPK activator 5-aminoimidazole-4-carboxyamide-ribonucleoside (AICAR) into the femoral artery increased skeletal muscle AMPK phosphorylation.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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