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Study · Animal study (in vivo) · mouse · 2025

4 results

Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.

Zhao Y, Ying X, Pang X, Lin Y, Shen J, Zhao Y, Shen W, Yang Y, Hong Z, Wu W, Hu X, Xie Q

Experimental neurology2 Feb 2025Cited by 4 (Europe PMC)

PMID39904418 (opens in a new tab)DOI10.1016/j.expneurol.2025.115174 (opens in a new tab)PepBankPUB-39904418
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In MCAO mice, AICAR reversed the loss of exercise-associated improvement in neurological dysfunction after Sesn2 silencing.

    In plain wordsIn mice with stroke, AICAR reversed the loss of exercise-associated neurological improvement after Sesn2 silencing.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNeurological dysfunction
    Study

    mousen: not reported in source

    MCAO with exercise pretreatment and Sesn2 shRNA
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, the administration of AICAR to activate the AMPK/TFEB signaling pathway significantly reversed the aforementioned effects.
    1 context sentence
    Summary · context
    Our findings revealed that in a middle cerebral artery occlusion (MCAO) mouse model, administration of Sesn2 shRNA abolished the neuroprotective effects induced by exercise pretreatment. These effects include improvements in neurological dysfunction and impaired autophagy, as well as a reduction in…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In MCAO mice, AICAR reversed the loss of exercise-associated improvement in impaired autophagy after Sesn2 silencing.

    In plain wordsIn mice with stroke, AICAR reversed the loss of exercise-associated improvement in impaired autophagy after Sesn2 silencing.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseImpaired autophagy
    Study

    mousen: not reported in source

    MCAO with exercise pretreatment and Sesn2 shRNA
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, the administration of AICAR to activate the AMPK/TFEB signaling pathway significantly reversed the aforementioned effects.
    1 context sentence
    Summary · context
    Our findings revealed that in a middle cerebral artery occlusion (MCAO) mouse model, administration of Sesn2 shRNA abolished the neuroprotective effects induced by exercise pretreatment. These effects include improvements in neurological dysfunction and impaired autophagy, as well as a reduction in…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In MCAO mice, AICAR reversed the loss of exercise-associated oxidative stress reduction after Sesn2 silencing.

    In plain wordsIn mice with stroke, AICAR restored exercise-associated oxidative stress reduction after Sesn2 silencing.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOxidative stress
    Study

    mousen: not reported in source

    MCAO with exercise pretreatment and Sesn2 shRNA
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, the administration of AICAR to activate the AMPK/TFEB signaling pathway significantly reversed the aforementioned effects.
    1 context sentence
    Summary · context
    Our findings revealed that in a middle cerebral artery occlusion (MCAO) mouse model, administration of Sesn2 shRNA abolished the neuroprotective effects induced by exercise pretreatment. These effects include improvements in neurological dysfunction and impaired autophagy, as well as a reduction in…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In MCAO mice, AICAR reversed the loss of exercise-associated neuroinflammation reduction after Sesn2 silencing.

    In plain wordsIn mice with stroke, AICAR restored exercise-associated neuroinflammation reduction after Sesn2 silencing.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNeuroinflammation
    Study

    mousen: not reported in source

    MCAO with exercise pretreatment and Sesn2 shRNA
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, the administration of AICAR to activate the AMPK/TFEB signaling pathway significantly reversed the aforementioned effects.
    1 context sentence
    Summary · context
    Our findings revealed that in a middle cerebral artery occlusion (MCAO) mouse model, administration of Sesn2 shRNA abolished the neuroprotective effects induced by exercise pretreatment. These effects include improvements in neurological dysfunction and impaired autophagy, as well as a reduction in…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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